supported by grants from the Beijing Natural Science Foundation(Grant No.7202132);CAMS Innovation Fund for Medical Sciences(CIFMS;Grant No.2016-I2M-02-002);“Significant New Drug Development”Major Science and Technology Development Projects of China(Grant No.2018ZX09711001-007-002)。
Objective:Death receptor 4(DR4;TRAIL-R1)critically mediates extrinsic apoptosis cascades via binding to TNF-related apoptosis-inducing ligand(TRAIL).However,intrinsic and/or acquired resistance are observed in the cli...
supported by the National Natural Science Foundation of China (Grant Nos. 11473001 and 11078006);support by the National Key Basic Research Program of China (Grant No. 2014CB845700);supported by the China Postdoctoral Science Foundation (Grant No. 2017M610695);supported by Special Funding for Advanced Users,budgeted and administrated by the Center for Astronomical Mega-Science, Chinese Academy of Sciences;a National Major Scientific Project which is built by the Chinese Academy of Sciences,funded by the National Development and Reform Commission, and operated and managed by the National Astronomical Observatories, Chinese Academy of Sciences
The stellar halo is one of the major components in the Milky Way. Research on its age can provide critical constraints on the origin of the stellar halo and further on the formation of our Galaxy.So far, different app...