supported by the grants from National Basic Research Program of China(No.2009CB521807);National S&T Major Special Project on Major New Drug Innovation(No.2009ZX09301-003);State-level public welfare scientific research institutes for basic R&D special fund(No.IMBF201101).
Human xenograft mouse models,which have been used in cancer research for over a century,provided significant advances for our understanding of this multifaceted family of diseases.Orthotopic transplantation tumor mode...