HDAC

作品数：138被引量：297H指数：8
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Class I histone deacetylases are major histone decrotonylases： evidence for critical and broad function of histone crotonylation in transcription被引量：25
《Cell Research》2017年第7期898-915,共18页Wei Wei Xiaoguang Liu Jiwei Chen Shennan Gao Lu Lu Huifang Zhang Guangjin Ding Zhiqiang Wang Zhongzhou Chen Tieliu Shi Jiwen Li Jianjun Yu Jiemin Wong 
We thank members of Wong＇s laboratory for valuable discussion.We thank Dr Cheng-Ming Chiang （UT Southwestern） for critical reading of the manuscript. This study is supported by grants from the National Science and Technology Major Project ＂Key New Drug Creation and Manufacturing Program＂ of China （2014ZX09507002- 005 to JW）, the Ministry of Science and Technology of China （2015CB910402 to JW）, the National Natural Science Foundation of China （81530078 and 31571325 to JW）, the Science and Tech- nology Commission of Shanghai Municipality （14XD1401700 and 11DZ2260300 to JW）.
Recent studies on enzymes and reader proteins for histone crotonylation support a function of histone crotonyla- tion in transcription. However, the enzyme（s） responsible for histone decrotonylation （HDCR） remains...
关键词：class I histone deacetylases histone decrotonylation histone deacetylation histone deacylation HDAC SIRT 
Histone deacetylase inhibitors attenuate P-algA1- induced cell proliferation and extracellular matrix synthesis in human renal mesangial cells in vitro被引量：4
《Acta Pharmacologica Sinica》2016年第2期228-234,共7页Qin DAI Jian LIU Yun-lei DU Xu HAO Ji YING Yun TAN Li-qun HE Wei-ming WANG Nan CHEN 
Aim： Aberrantly glycosylated IgA1 is a key factor in the pathogenesis of IgA nephropathy （IgAN）. In this study we investigated the effects of aggregated IgA1 derived from IgAN patients （P-algA1） on human renal me...
关键词：IgA nephropathy human renal mesangial cells HDAC trichostatin A valproic acid extracellular matrix synthesis SMAD2/3 STAT3 antifibrosis 
Reversible Histone Acetylation Involved in Transcriptional Regulation of WT1 Gene被引量：4
《Acta Biochimica et Biophysica Sinica》2007年第12期931-938,共8页Yangguang SHAO Jun LU Cao CHENG Liguo CUI Guoping ZHANG Baiqu HUANG 
This work was supported by. the grants from the National Basic Research Project of China （No. 2005CB522404） and the National Natural Science Foundation of China （No. 30571698） We thank Drs. Joan BOYES, Paul M. LIEBERMAN, Richard M. POPE, Odd S. GABRIELSEN, Thierry ROGER, Mary TZUKERMAN, and Edward SETO for providing plasmid constructs.
To validate the involvement of reversible histone acetylation in the transcriptional regulation of human Wilms＇ tumor 1 gene （WT1）, we analyzed the roles of histone deacetylases （HDACs） and histone acetyltransfer...
关键词：histone acetylation WT1 HDAC P300/CBP transcriptional regulation 
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