HDAC

作品数：138被引量：295H指数：8
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Structural basis for nucleosome binding and catalysis by the yeast Rpd3S/HDAC holoenzyme
《Cell Research》2023年第12期971-974,共4页Yueyue Zhang Mengxue Xu Po Wang Jiahui Zhou Guangxian Wang Shuailong Han Gang Cai Xuejuan Wang 
This study was supported by the Strategic Priority Research Program of the Chinese Academy of Sciences(XDB37010000);the National Natural Science Foundation of China(31922035,32030057,31890783,and32271255);the Fundamental Research Funds for the Central Universities(WK9100000032 and YD2070002012).
Dear Editor,Histone deacetylases(HDACs)are evolutionally conserved enzymes that remove acetyl modifications from histones and play a central role in epigenetic gene silencing.1 Class I HDACs are promising targets for ...
关键词：NUCLEOSOME CATALYSIS REMOVE 
Class I histone deacetylases are major histone decrotonylases： evidence for critical and broad function of histone crotonylation in transcription被引量：24
《Cell Research》2017年第7期898-915,共18页Wei Wei Xiaoguang Liu Jiwei Chen Shennan Gao Lu Lu Huifang Zhang Guangjin Ding Zhiqiang Wang Zhongzhou Chen Tieliu Shi Jiwen Li Jianjun Yu Jiemin Wong 
We thank members of Wong＇s laboratory for valuable discussion.We thank Dr Cheng-Ming Chiang （UT Southwestern） for critical reading of the manuscript. This study is supported by grants from the National Science and Technology Major Project ＂Key New Drug Creation and Manufacturing Program＂ of China （2014ZX09507002- 005 to JW）, the Ministry of Science and Technology of China （2015CB910402 to JW）, the National Natural Science Foundation of China （81530078 and 31571325 to JW）, the Science and Tech- nology Commission of Shanghai Municipality （14XD1401700 and 11DZ2260300 to JW）.
Recent studies on enzymes and reader proteins for histone crotonylation support a function of histone crotonyla- tion in transcription. However, the enzyme（s） responsible for histone decrotonylation （HDCR） remains...
关键词：class I histone deacetylases histone decrotonylation histone deacetylation histone deacylation HDAC SIRT 
Smek promotes histone deacetylation to suppress transcription of Wnt target gene brachyury in pluripotent embryonic stem cells被引量：2
《Cell Research》2011年第6期911-921,共11页Jungmook Lyu Eek-hoon Jho Wange Lu 
In embryonic stem cells （ESCs）, Wnt-responsive development-related genes are silenced to maintain pluripotency and their expression is activated during differentiation. Acetylation of histones by histone acetyltrans...
关键词：embryonic stem cell Smek HDAC 1 protein phosphatase 4 complex Wnt signaling differentiation 
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