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作品数:140被引量:137H指数:6
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相关领域:理学医药卫生更多>>
相关作者:白越闫冰宫勋赵常均彭程更多>>
相关机构:宝图设计有限公司北京大学中国科学院长春光学精密机械与物理研究所中国科学院大学更多>>
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相关基金:国家自然科学基金国家重点基础研究发展计划国家科技支撑计划中国博士后科学基金更多>>
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  • 期刊=Chinese Chemical Lettersx
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The hit-to-lead optimization of 1,2,3,4,4a,9a-hexahydro-1H-xanthenes as glucocorticoid receptor antagonists
《Chinese Chemical Letters》2014年第5期693-698,共6页Yan-Hui Zhu Meng Zhang Qun-Yi Li Qing Liu Jie Zhang Yun-Yun Yuan Fa-Jun Nan Ming-Wei Wang 
supported in part by grants from the Ministry of Health of China (Nos. 2012ZX09304-011, 2013ZX09401003-005, 2013ZX09507001 and 2013ZX09507002);Shanghai Science and Technology Development Fund (No. 13DZ2290300);Thousand Talents Program in China
The structure–activity relationship(SAR) study of a 1 2 3 4 4a 9a-hexahydro-1H-xanthene series of selective,human glucocorticoid receptor a(hGRa) antagonists is reported.Compounds were screened using hydroxyapati...
关键词:Glucocorticoid receptor Antagonist 1 2 3 4 4a 9a-Hexahydroxanthene Structure–activity relationship Lead optimization 
Synthesis of 5-Substituted Hexahydro-1H-1, 4-Diazepine Analogues
《Chinese Chemical Letters》2001年第11期951-954,共4页Jing Shan SHEN Li Jun LEI Hai Fang MAO Jian Feng LI Ru Yun JI 
5-Substituted hexahydro-1H-1,4-diazepine analogues were synthesized starting from N,N'-dibenzyl-1, 2-ethylenediamine and methyl 2, 4-dibromide butyrate through nucleophilic substitution, reduction, chlorination, deben...
关键词:5-substituted hexahydro-1H-1 4-diazepine analogues synthesis bioactivity 
Synthesis of 2-Substituted Hexahydro-1H-1,4-diazepine Analogues
《Chinese Chemical Letters》2001年第3期193-194,共2页Jing Shan SHEN Li Jun LEI Tie Ma YAN Jian Feng LI Hui Jun LI Zhen Hua LI Ru Yun JI 
the Shanghai Development Fund of Science and Technology.
substituted hexahydro-1H-1,4-diazepine analogues were synthesized starting from N,N?-dibenzyl-1,3-propylene diamine and methyl-2,3-dibromo propionate through nucleophilic substitution, reduction, chlorination and debe...
关键词:Hexahydro-1H-1 4-diazepine analogues synthesis nucleophilic substitution reduction chlorination debenzylation. 
A New Binuclear Bisphthaloeyanine: Tetrahydroxo(hexa-tetradecanobisphthalocyaninato) Disilicium
《Chinese Chemical Letters》1999年第6期459-462,共4页Dai Hua TANG Xiao Bing WANG Zhen ZHEN Feng Qi WANG Xin Hou LIU(Institute of Photographic Chemistry. Chinese Academy of Sciences. Beijing 100101) 
A new binuclear bisphthalocyanine-tetrahydroxo(hexa-tetradecanobisphthalocyani-nato) disilicum is synthesized and characterized. and one of its important applications isintroduced.
关键词:Binuclear bisphthalocyanine synthesis double-axial linear phthalocyanine 
Diels-Alder Reactions of 3-Carboethoxy- and 3-Carbonitrile-2-Cyclohexen-1-one
《Chinese Chemical Letters》1998年第3期233-234,共2页Wen Qian YANG Shi Zhi CHEN Liang HUANG(Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union MedicalCollege Beijing 100050) 
Aluminum chloride induced Diels-Alder reactions of 3-carboethoxy- and 3-carbonitrile-2-cyclohexen-1-one with cyclopentadiene, isoprene and (E)-piperylene were described. Thestereochemistry of the adducts were confirme...
关键词:Diels-Alder reaction base-induced isomerization 
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