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作品数：569被引量：1187H指数：16
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ROS-responsive nanoparticle delivery of ferroptosis inhibitor prodrug to facilitate mesenchymal stem cell-mediated spinal cord injury repair被引量：1
《Bioactive Materials》2024年第8期438-454,共17页Renshuai Hua Chenxi Zhao Zhengyu Xu Derong Liu Wenyuan Shen Wenlu Yuan Yan Li Jun Ma Zhishuo Wang Shiqing Feng 
supported by the National Key Research and Development Project of Stem Cell and Transformation Research(2019YFA0112100);Tianjin Key Medical Discipline(Specialty)Construct Project(TJYXZDXK-027A);International Innovation Summit for Academicians and Experts(22JRRCRC00010).We thank the Large Instrument Sharing Platform of Tianjin Medical University for the availability of the instruments.
Spinal cord injury(SCI)is a traumatic condition that results in impaired motor and sensory function.Ferroptosis is one of the main causes of neural cell death and loss of neurological function in the spinal cord,and f...
关键词：Spinal cord injury Huc-MSCs ROS-Responsive nanoparticles Ferroptosis inhibitor 
A ROS-responsive hydrogel incorporated with dental follicle stem cell-derived small extracellular vesicles promotes dental pulp repair by ameliorating oxidative stress被引量：1
《Bioactive Materials》2024年第6期524-540,共17页Mengjie Li Jun Tian Kangkang Yu He Liu Xiaoqi Yu Nan Wang Qimei Gong Kun Li Ya Shen Xi Wei 
supported by the National Natural Science Foundation of China(No.82370943,82201037 and 81970925);the Young Elite Scientists Sponsorship Program by Guangzhou(QT-2023-030);Fundamental Research Funds for the Central Universities,Sun Yat-sen University(23qnpy157).
Pulpitis,an inflammatory disease of dental pulp tissues,ultimately results in the loss of pulp defense properties.Existing clinical modalities cannot effectively promote inflamed pulp repair.Oxidative stress is a majo...
关键词：Small extracellular vesicle Dental follicle stem cell Pulpitis Oxidative stress ROS-Responsive hydrogel 
HDAC I/IIb selective inhibitor Purinostat Mesylate combined with GLS1 inhibition effectively eliminates CML stem cells被引量：1
《Bioactive Materials》2023年第3期483-498,共16页Qiang Qiu Linyu yang Yunyu Feng Zejiang Zhu Ning Li Li Zheng Yuanyuan Sun Cong Pan Huandi Qiu Xue Cui Wei He Fang Wang Yuyao Yi Minghai Tang Zhuang Yang Yunfan Yang Zhihui Li Lijuan Chen Yiguo Hu 
Fundamental Research Funds for the Central Universities(2021SCU12022 to L.Yang);the 1.3.5 Project for Disciplines of Excellence(to Z.Li and L.Chen);West China Hospital,Sichuan University,the National Natural Science Foundation of China(82104211 to L.Yang);National Natural Science Foundation of China(81541092 and 81770103 to Y.Hu).
Purinostat Mesylate(PM)is a novel highly selective and active HDAC I/IIb inhibitor,and the injectable formulation of PM(PMF)based on the compound prescription containing cyclodextrin completely can overcome PM’s poor...
关键词：Chronic myelogenous leukemia Leukemia stem cell Selective HDAC I/IIb inhibitor GLS1 Mouse model 
Modulating autophagic flux via ROS-responsive targeted micelles to restore neuronal proteostasis in Alzheimer’s disease被引量：3
《Bioactive Materials》2022年第5期300-316,共17页Shuting Xu Peng Yang Kang Qian Yixian Li Qian Guo Pengzhen Wang Ran Meng Jing Wu Jinxu Cao Yunlong Cheng Minjun Xu Qizhi Zhang 
supported by National Natural Science Foundation of China(No.82073780 and 81690263);Shanghai Municipal Natural Science Foundation(No.19ZR140620).
Compromised autophagy and defective lysosomal clearance significantly contribute to impaired neuronal proteostasis,which represents a hallmark of Alzheimer’s disease(AD)and other age-related neurodegenerative disorde...
关键词：Autophagic flux ROS-Responsive micelle system Brain-neuron targeting Rapamycin Alzheimer’s disease 
A ROS-responsive,self-immolative and self-reporting hydrogen sulfide donor with multiple biological activities for the treatment of myocardial infarction被引量：5
《Bioactive Materials》2022年第3期168-182,共15页Mengyun Yao Yifei Lu Lin Shi Yong Huang Qing Zhang Jianglin Tan Ping Hu Jianxiang Zhang Gaoxing Luo Ning Zhang 
This work was supported by the National Natural Science Foundation of China(Nos.82002044&82002045);China Postdoctoral Science Foundation(No.2019M663976);and Natural Science Foundation of Chongqing(No.cstc2020jcyj-bshX0014).
Myocardial infarction(MI),as one of the leading causes of global death,urgently needs effective therapies.Recently,hydrogen sulfide(H2S)has been regarded as a promising therapeutic agent for MI,while its spatiotempora...
关键词：Hydrogen sulfide donor Reactive oxygen species Myocardial infarction Molecular imaging Theranostic agent 
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