This work was also supported by the Ministry of Science and Technology of China(2016YFA0100400);the Chinese Academy of Sciences(XDB39000000 and QYZDY-SSW-SMC031);Z.Z.is sponsored by the Youth Innovation Promotion Association(2017133)of the Chinese Academy of Sciences.
We apologize for the mistake of the fund information in the acknowledgements.The correct information is as follows.This correction does not affect the conclusion of the work.
This work was primarily supported by the National Natural Science Foundation of China(31530047);This work was also supported by the Ministry of Science and Technology of China(2016YFA0100400);the Chinese Academy of Sciences(XDB39000000 and QYZDYSSW-SMC031);Z.Z.is sponsored by the Youth Innovation Promotion Association(2017133)of the Chinese Academy of Sciences.
Mitotic inheritance of the DNA methylome is a challenging task for the maintenance of cell identity.Whether DNA methylation pattern in different genomic contexts can all be faithfully maintained is an open question.A ...
This study was supported by grants from the Swiss National Science Foundation(160734)to T.D.H.and from the Danish National Research Foundation(DNRF115);the Nordea Foundation,and the Novo Nordisk Foundation to I.D.H.
DNA replication stress,a feature of human cancers,often leads to instability at specific genomic loci,such as the common fragile sites(CFSs).Cells experiencing DNA replication stress may also exhibit mitotic DNA synth...
This work was supported by grants to Songmin Ying from the Ministry of Science and Technology of China(2016YFA0100301);the National Natural Science Foundation of China(81870007,81920108001);the Zhejiang Provincial Natural Science Foundation(LD19H160001);the Zhejiang Provincial Program for the Cultivation of High-Level Innovative Health Talents(2016-63).
Common fragile sites(CFSs)are genomic loci prone to the formation of breaks or gaps on metaphase chromosomes.They are hotspots for chromosome rearrangements and structural variations,which have been extensively implic...
The commonly used antimitotic chemotherapeutic agents such as taxol and vinblastine arrest cell cycle progression by disrupting mitotic spindles, and cause cancer cells to undergo apoptosis through 'mitotic catastro...
Once generated, neurons are thought to permanently exit the cell cycle and become irreversibly differentiated. However, neither the precise point at which this post-mitotic state is attained nor the extent of its irre...
Progression through the cell cycle is largely dependent on waves of periodic gene expression, and the regulatory networks for these transeriptome dynamics have emerged as critical points of vulnerability in various as...
The inheritance of human genome through mitosis is precisely regulated by a series of tightly orchestrated events such as chromosome condensation, bi-orientated spindle formation, chromosome congression,