Supported by Chinese Scientific and Technological Major Special Project(2012ZX09301003-002-003);the National Natural Science Foundation of China to J.X.(30600759,91129708);State Key Lab of Space Medicine Fundamentals and Application(SMFA)to J.X(SMFA09A07,SMFA10A03);Advanced Space Medico-Engineering Research Project of China(01111014,01111016)