the National Natural Science Foundation of China,No.81503406;the China Postdoctoral Science Foundation,No.2017M6232;the Special Fund for Traditional Chinese Medicine by the Health Department of Guangxi Zhuang Autonomous Region,No.GZBZ16-07,GZLC16-23;the Natural Science Foundation of Guangxi Zhuang Autonomous Region,No.2014GXNSFAA118177~~