国家自然科学基金(81571283)%山东省自然科学基金(ZR2016HL21,ZR2017LH068)%山东省中医药科技发展计划项目(2015-420)National Natural Science Foundation of China(81571283)%Natural Science Foundation of Shandong Province(ZR2016HL21,ZR2017LH068)%Traditional Chinese Medicine Science and Technology Development Project of Shandong Province(2015-420)