长期情志不畅肝失疏泄影响认知灵活性的ERPs研究  

An ERPs study on the effect of long-term emotional disturbance and liver failure on cog-nitive flexibility

作　　者：王格格 周理乐 刘永[1] 侯俊林[1] 赵紫薇 秦中朋 高安祺 许琳培 詹向红[1] Wang Ge-ge;ZHOU Li-le;LIU Yong;HOU Jun-lin;ZHAO Zi-wei;QIN Zhong-peng;GAO An-qi;XU Lin-pei;ZHAN Xiang-hong(Henan University of Chinese Medicine,Henan Province Engineering Technology Research Center for Chinese and Western Integrative Prevention and Treatment of Brain Cognitive Disease,Zhengzhou Key Laboratory for Chinese&Western Integrative Prevention and Treatment of Brain Cognitive Disease,Zhengzhou,Henan 450046,China)

机构地区：[1]河南中医药大学认知神经科学实验室,河南省中西医结合防治脑认知疾病工程技术研究中心,郑州市中西医结合防治脑认知疾病重点实验室,河南郑州450046

出　　处：《时珍国医国药》2023年第5期1269-1273,共5页Lishizhen Medicine and Materia Medica Research

基　　金：国家自然科学基金面上项目(81473556,81873208);河南中医药大学2021年度研究生科研创新基金项目(2021KYCX061)

摘　　要：目的研究长期情志不畅人群因肝失疏泄存在认知灵活性受损,并在神经电生理层面探寻受损机制。方法根据艾森克人格问卷神经质维度得分筛选出高、低神经质被试,分别纳入长期情志不畅组与情志畅达对照组各53名病例。结合事件相关电位技术,采集及分析被试完成More-odd shifting任务转换范式的正确率、反应时、转换代价等行为学数据,及P2、P3成分波幅、潜伏期数据。结果(1)长期情志不畅组在完成重复任务时正确率显著低于情志畅达对照组(P<0.05);(2)长期情志不畅组完成任务转换范式所付出的转换代价显著高于情志畅达对照组(P<0.05);(3)长期情志不畅人群在重复任务与转换任务下P2波幅均显著大于情志畅达对照组(P<0.05)。结论长期情志不畅肝失疏泄是认知灵活性受损的可能原因,其受损机制与刺激-反应关联能力下降有关。Objective To investigate whether people with long-term emotional disturbance have impaired cognitive flexibility due to liver failure,and to explore the damage mechanism at the neuroelectrophysiological level.Methods According to the neuroticism dimension score of the Eysenck Personality Questionnaire,subjects with high and low neuroticism were screened,and 53 subjects were included in the long-term emotional disturbance group and the emotionally smooth control group,respectively.Combined with event-related potential technology,behavioral data such as the accuracy rate,reaction time,and switching cost of the subjects completing the More-odd shifting task were collected and analyzed,as well as the amplitude and latency data of P2 and P3 components.Results(1)The accuracy rate of the long-term emotional disturbance group in completing repetitive tasks was significantly lower than that of the emotionally-smooth control group(P<0.05);(2)The long-term emotional disturb-ance group had to pay for the conversion cost of completing the task switching paradigm.It was significantly higher than that of the emotionally smooth control group(P<0.05);(3)The P2 amplitude of the long-term emotionally impaired group was significantly greater than that of the emotionally smooth control group under repetitive tasks and switching tasks(P<0.05).Conclusion Long-term emotional disturbance and hepatic insufficiency are the possible reasons for impaired cognitive flexibility,and the impaired mechanism is related to the decreased ability of stimulus-response association.

关 键 词：认知灵活性 肝失疏泄 情志不畅 任务转换 

分 类 号：R228[医药卫生—中医基础理论]