塞来昔布联合化疗治疗晚期胃癌疗效与安全性Meta分析  

Efficacy and safety of celecoxib combined with chemotherapy versus chemortherapy alone in the treatment of advanced gastric cancer:a meta-analysis

作　　者：吴戈[1] 蔡瑜[1] 贾媛媛 李武军[1,2] 于照祥 张青青[1] WU Ge;CAI Yu;JIA Yuanyuan(First Affiliated Hospital Of Xi’an Medical University,Xi’an 710077)

机构地区：[1]西安医学院第一附属医院,西安710077 [2]西藏自治区阿里地区人民医院,阿里859000

出　　处：《陕西医学杂志》2020年第3期364-369,共6页Shaanxi Medical Journal

基　　金：西藏自治区阿里地区科技创新支撑类自然科学基金资助项目(AKKCZRJJ20180207).

摘　　要：目的:系统性评价塞来昔布联合化疗治疗晚期胃癌的有效性、安全性。方法:检索CNKI知网、万方、维普和Pub Med数据库,搜集塞来昔布联合化疗治疗晚期胃癌的随机对照试验(RCT),检索时限为建库至2018年12月10日。在评价纳入研究的偏倚风险后,采用Stata14.0软件进行Meta分析。结果:共纳入8个RCT,结果显示塞来昔布联合化疗组治疗有效率[RR=1.42,95%CI(1.21~1.68),P<0.001]、疾病控制率[RR=1.15,95%CI(1.04~1.27),P<0.001]、生活质量改善状况[RR=1.61,95%CI(1.32~1.95),P<0.001]均优于常规化疗组,并且可降低恶心呕吐[RR=0.81,95%CI(0.69~0.96),P=0.014]、血小板减少[RR=0.78,95%CI(0.64~0.96),P=0.017]事件的发生率,但两组在贫血、白细胞减少、腹泻、手足综合征、外周神经炎等事件发生率方面比较差异无统计学意义。结论:塞来昔布联合化疗较单纯化疗在晚期胃癌治疗方面的疗效更好,且安全性较好。Objectives:To systematically review the efficacy and safety of celecoxib combined with chemotherapy for advanced gastric cancer.Methods:Databases including VIP,CNKI,WanFang Data and PubMed were electronically searched from inception to December 2018 to collect randomized controlled trials(RCT)on celecoxib combined with chemotherapy versus chemotherapy alone for advanced gastric cancer.After evaluating the risk of bias in the included studies,Stata 14.0 software was used for meta-analysis.Results:A total of 8 RCTs were included.The results of meta-analysis showed that the therapeutic efficacy(RR=1.42,95%CI 1.21 to 1.68,P<0.001),disease control rate(RR=1.15,95%CI 1.04 to 1.27,P<0.001),and quality of life improvement(RR=1.61;95%CI,1.32 to 1.95;P<0.001)of celecoxib combined with chemotherapy group were superior to those of conventional chemotherapy group.Moreover,the incidence of nausea and vomiting(RR=0.81,95%CI 0.69 to 0.96,P=0.014),and thrombocytopenia(RR=0.78,95%CI 0.64 to 0.96,P=0.017)was reduced,but there was no statistical difference in the incidence of events such as anemia,leukopenia,diarrhea,hand-foot syndrome,and peripheral neuritis.Conclusion:Celecoxib combined with chemotherapy is more effective and safer than chemotherapy alone in the treatment of advanced gastric cancer.

关 键 词：塞来昔布 环氧化酶2抑制剂 胃癌 系统评价 META分析 安全性 

分 类 号：R735.2[医药卫生—肿瘤]