仙灵补血冲剂联合注射用香菇多糖治疗结直肠癌辅助化疗所致骨髓抑制效果观察  

Effect of Xianling Buxue granule combined with lentinan for injection on bone marrow suppression caused by postoperative chemotherapy for colorectal cancer

作　　者：王鲁军[1] 栾祖鹏[2] 马敏[2] WANG Lu-jun;LUAN Zu-peng;MA Min(Department of Geriatric and Chronic Diseases,Jinan Third People's Hospital,Jinan 250101,China)

机构地区：[1]济南市第三人民医院中医科,山东济南250101 [2]济南市第三人民医院综合治疗二科,山东济南250101

出　　处：《社区医学杂志》2022年第9期500-504,共5页Journal Of Community Medicine

摘　　要：目的探讨应用仙灵补血冲剂联合注射用香菇多糖治疗结直肠癌患者辅助化疗导致的骨髓抑制的效果。方法选取2017-01-01-2021-12-31济南市第三人民医院收治的结直肠癌患者66例作为研究对象。应用仙灵补血冲剂联合注射用香菇多糖治疗的33例患者作为观察组,应用香菇多糖治疗的33例患者作为对照组。比较2组患者骨髓抑制情况、血常规、免疫功能、生活质量以及不良反应。结果治疗后1个月,观察组骨髓抑制率(χ^(2)=7.791,P<0.001)和抑制程度(Z=8.541,P<0.001)均低于对照组,差异有统计学意义;观察组白细胞水平为(3.42±0.15)×10^(9)L^(-1),高于对照组的(2.88±0.14)×10^(9)L^(-1),t=15.119,P<0.001;血红蛋白水平为(110.27±10.36)g/L,高于对照组的(96.56±9.54)g/L,差异有统计学意义,t=5.592,P<0.001;血小板水平为(132.68±13.21)×10^(9)L^(-1),高于对照组的(125.10±10.96)10^(9)L^(-1),差异有统计学意义,t=2.537,P<0.001。观察组CD4^(+)水平为(50.76±6.35)%,高于对照组的(34.23±6.01)%,差异有统计学意义,t=10.861,P<0.001;CD8^(+)水平为(29.21±4.01)%,高于对照组的(25.14±3.28)%,差异有统计学意义,t=4.513,P<0.001;CD4^(+)/CD8^(+)水平为1.93±0.09,高于对照组的1.25±0.14,差异有统计学意义,t=23.471,P<0.001;CD3^(+)水平为(70.16±5.39)%,高于对照组的(58.21±4.87)%,差异有统计学意义,t=9.450,P<0.001。观察组生活质量评分为(80.25±1.23)分,高于对照组的(68.36±1.65)分,差异有统计学意义,t=33.189,P<0.001。2组不良反应发生率差异无统计学意义。结论仙灵补血冲剂联合注射用香菇多糖具有促进和保护骨髓造血,升高白细胞,增强机体免疫功能效果,且不增加不良反应。Objective To investigate the effect of Xianling Buxue granule combined with lentinan for injection on bone marrow suppression caused by postoperative chemotherapy in patients with colorectal cancer.Methods Patients with colorectal cancer treated in Jinan Third People's Hospital from January 1,2017to December 31,2021were selected as the research object.33patients treated with Xianling Buxue granule combined with lentinan for injection were selected as the observation group,and 33patients treated with lentinan were selected as the control group.The bone marrow suppression,blood routine,immune function,quality of life and adverse reactions were compared between the two groups.Results One month after treatment,the bone marrow suppression rate of the observation group(χ^(2)=7.791,P<0.001)and the degree of inhibition(Z=8.541,P<0.001)were significantly lower than those in the control group.The level of leukocytes in the observation group was(3.42±0.15)×10^(9)L^(-1),which was higher than that in the control group(2.88±0.14)×10^(9)L^(-1),t=15.119,P<0.001;The hemoglobin level was(110.27±10.36)g/L,which was higher than that in the control group(96.56±9.54)g/L,t=5.592,P<0.001;The platelet level was(132.68±13.21)×10^(9)L^(-1),which was higher than(125.10±10.96)×10^(9)L^(-1)in the control group,t=2.537,P<0.001.The level of CD4^(+)in the observation group was(50.76±6.35)%,which was higher than that in the control group(34.23±6.01)%,t=10.861,P<0.001;The level of CD8^(+)was(29.21±4.01)%,which was higher than that in the control group(25.14±3.28)%,t=4.513,P<0.001;The level of CD4^(+)/CD8^(+)was 1.93±0.09,higher than 1.25±0.14in the control group,t=23.471,P<0.001;The level of CD3^(+)was(70.16±5.39)%,which was higher than that in the control group(58.21±4.87)%,t=9.450,P<0.001.The score of quality of life in the observation group was(80.25±1.23)poin,which was higher than that in the control group(68.36±1.65)poin,t=33.189,P<0.001.There was no significant difference in the incidence of adverse reactions between the

关 键 词：仙灵补血冲剂 香菇多糖 结直肠癌 化疗 骨髓抑制 

分 类 号：R735.34[医药卫生—肿瘤]