肠道菌群与前列腺癌发生发展的相关机制  

Relationship between gut microbiota and the pathogenesis of prostate cancer

作　　者：陈建舟 马志方[1] 李洪燕 张华俊 郐海洋 石明凯 CHEN Jianzhou;MA Zhifang;LI Hongyan;ZHANG Huajun;KUAI Haiyang;SHI Mingkai(Department of Urology,First Hospital of Shanxi Medical University,Taiyuan 030001,China;Shanxi Provincial Cancer Hospital,Taiyuan 030013,China;Department of Urology,Shanxi Bethune Hospital,Taiyuan 030032,China)

机构地区：[1]山西医科大学第一医院泌尿外科,太原030001 [2]山西省肿瘤医院,太原030013 [3]山西白求恩医院泌尿外科,太原030032

出　　处：《生命的化学》2022年第12期2165-2170,共6页Chemistry of Life

摘　　要：本文探讨了前列腺癌(prostatic cancer,PCa)与肠道菌群发生发展的关系,并从高脂饮食通过肠道菌群影响前列腺癌的发生发展、肠道菌群影响睾酮代谢及前列腺癌激素抵抗等方面进一步探究肠道菌群促进前列腺癌发生发展的可能机制,并阐述了肠道菌群与前列腺癌的诊断、治疗及预后的新进展,同时也为将来的治疗方向提供新的思路。This paper discusses the relationship between prostate cancer(PCa)and the occurrence and development of intestinal flora,and further explores the possible mechanism of intestinal flora in promoting the occurrence and development of prostate cancer from the aspects of high-fat diet affecting the occurrence and development of prostate cancer through intestinal flora,intestinal flora affecting testosterone metabolism and hormone resistance of prostate cancer,and expounds the new progress in the diagnosis,treatment and prognosis of intestinal flora and prostate cancer,and also provides new ideas for the future treatment direction.

关 键 词：前列腺癌 肠道菌群 高脂饮食 CRPC 

分 类 号：R737.25[医药卫生—肿瘤]