A Study of Normal Epidermal Melanocyte Distribution  

作　　者：Kai-Lv Sun Wan Liu Xiao-Man Gao Min Yang Jian-Min Chang 

机构地区：[1]Department of Dermatology,Beijing Hospital,National Center of Gerontology,Institute of Geriatric Medicine,Chinese Academy of Medical Sciences,Beijing 100730,China

出　　处：《International Journal of Dermatology and Venereology》2021年第1期32-35,共4页国际皮肤性病学杂志（英文）

摘　　要：Objective:To elucidate the epidermal melanocyte distribution according to sex,age,and body part with the goal of providing benchmark data for the diagnosis and therapeutic effect evaluation of pigmentary skin diseases.Methods:Epidermal melanocytes and keratinocytes were assessed using direct immunofluorescence staining,and the melanocyte density and epidermal thickness were calculated.The obtained data were statistically analyzed using SPSS Version 20.0 software.An independent-samples t test was used to compare the data between two groups,while data among three or more groups were compared by one-way analysis of variance.Data correlations were evaluated using Pearson correlation analysis.Results:Melanocytes were uniformly distributed among the keratinocytes in the basal layer,and the average ratio of melanocytes to keratinocytes was 1:7.Among them,the ratio in males was 1:6.5 and that in females was 1:7.4,with no significant difference(P=0.127).The melanocyte density gradually declined as age increased;the ratio was 1:5.8 before 50 years of age without an obvious downtrend.The average melanocyte density was 1:7.9 within 51 to 65 years of age and 1:8.5 at>65 years of age,and the difference was statistically significant(P<0.01).Obvious differences were found in the melanocyte density among different body parts;in descending order,these densities were as follows:face(1:4.0)>neck(1:5.1)>hip(1:5.7)>upper limb(1:7.4)>lower limb(1:8.3)>lower back(1:9.2)>thorax and abdomen(1:9.9).The melanocyte density was not related to the epidermal thickness.Conclusion:The melanocyte density showed a declining trend with age and significantly changed after 50 years of age.The melanocyte density was associated with body part;specifically,the density in the face,neck,and hip was higher than that in the limbs and torso.However,the melanocyte density was not associated with sex or epidermal thickness.

关 键 词：DISTRIBUTION IMMUNOFLUORESCENCE MELANOCYTES 

分 类 号：R329.2[医药卫生—人体解剖和组织胚胎学]