The pharmacokinetics of aspirin in combination with total ginsenoside of ginseng stems and leaves in rats  

作　　者：Gangyan Yu Li Tan Yutao Xue Mengdi Zhao Yang Lu 

机构地区：[1]Department of Industrial Pharmacy,School of Chinese Pharmacy,Beijing University of Chinese Medicine,Beijing 100029,China

出　　处：《Journal of Traditional Chinese Medical Sciences》2017年第4期366-371,共6页中医科学杂志（英文）

摘　　要：Objective:To investigate the effect of total ginsenoside of ginseng stems and leaves (TGSL) on the pharmacokinetics of aspirin in rats.Methods:Sprague-Dawley rats were randomly divided into two groups (n =6),a combined group that received TGSL (625 mg/kg body weight) and aspirin (10 mg/kg body weight) by gavage,and an aspirin group that received aspirin (10 mg/kg body weight) by gavage.The concentration of salicylic acid,an important metabolite of aspirin,was determined by highperformance liquid chromatography in supernatant from blood obtained from the orbital sinus at various time points to examine the effect of TGSL on aspirin.Results:The results showed that the Tmax of salicylic acid was [0.92 (0.58)] hours in the aspirin group and [2.50 (1.22)] hours in the combined group,and was statistically significantly different between the groups (p <.05).Conclusions:TGSL can affect the pharmacokinetics of aspirin at Tmax in rats.

关 键 词：ASPIRIN TOTAL GINSENOSIDE of GINSENG STEMS and leaves (TGSL) PHARMACOKINETICS 

分 类 号：R965[医药卫生—药理学]