MicroRNA-126 is a prospective target for vasculardisease  

作　　者：Mei-Jie Qu Jia-Ji Pan Xiao-Jing Shi Zhi-Jun Zhang Yao-Hui Tang Guo-Yuan Yang 

机构地区：[1]Department of Neurology,Ruijin Hospital,Shanghai Jiao Tong University School of Medicine,Shanghai 200025,China [2]Neuroscience and Neuroengineering Research Centre,Med-X Research Institute and School of Biomedical Engineering,Shanghai Jiao Tong University,Shanghai 200030,China

出　　处：《Neuroimmunology and Neuroinflammation》2018年第4期1-7,共7页神经免疫与神经炎症（英文版）

基　　金：This study was supported by grants from the National Key Research and Development Program of China(2016YFC1300600);the National Natural Science Foundation of China(81471178,GYY,81522015,YTW,81771251,GYY,81771244,ZJZ);K.C.Wong Education Foundation;the Science and Technology Commission of Shanghai Municipality(17ZR1413600,ZJZ).

摘　　要：MicroRNA-126 was involved in angiogenesis during physiological and pathological process. It was mainly expressed in endothelial cells, and defined as a pivotal biological molecule associated with vascular disease. Increased microRNA-126 in endothelial cells promotes angiogenesis in ischemic stroke, repairs impaired endothelial cells in atherosclerosis, and attenuates vascular dysfunction in diabetics. By contrast, microRNA-126 transferred from endothelial cell to smooth muscle cells could lead to proliferation that induced intimal hyperplasia. Additionally, microRNA-126 could be a tumor suppressor or an oncogene, which was depended on the cancer type. In this review, we summarized the function of microRNA-126 in ischemic stroke, atherosclerosis, diabetics, tumor, and discussed the underlying mechanisms.

关 键 词：ATHEROSCLEROSIS DIABETES ISCHEMIA microRNA-126 

分 类 号：R73[医药卫生—肿瘤]