Clinical study of adjuvant therapy on ischemic stroke with salviae miltiorrhizae and ligustrazine  

作　　者：Jing-Qin Tian Wei Zhang 

机构地区：[1]Seventh Department of Encephalopathy,Weifang Hospital of Traditional Chinese Medicine,Weifang 261041,Shandong,China [2]Second Department of Encephalopathy,Weifang Hospital of Traditional Chinese Medicine,Weifang 261041,Shandong,China

出　　处：《Journal of Acute Disease》2017年第1期36-40,共5页急性病杂志（英文版）

摘　　要：Objective: To study the effect of adjuvant therapy with salviae miltiorrhizae and ligustrazine injection on neural function injury, degree of oxidative stress reaction, chemotactic factor and adhesion molecule in patients with ischemic stroke. <br> Methods: Patients with ischemic stroke admitted in our hospital from August 2013 to October 2015 were retrospectively analyzed and divided into conventional treatment (CT) group receiving conventional treatment and traditional Chinese medicine auxiliary (TCMA) group receiving adjuvant therapy with salviae miltiorrhizae and ligustrazine injection. After the treatment of the first month and the third month, serum was collected to detect the contents of nerve injury molecules, oxidative stress parameters, chemotactic factor and adhesion molecule. <br> Results: After the 4-week treatment, the contents of serum neuron specific enolase, S100 calcium-binding protein B, heart-type fatty acid binding protein, malondialdehyde, advanced oxidation protein products, 8-hydroxy-2'-deoxyguanosine, monocyte chemoattractant protein-1,CD40,CD40 ligand, vascular endothelial cadherin, soluble intercellular adhesion molecule 1 and soluble vascular adhesion molecule 1 in patients ofTCMA group were all significantly lower than those of CT group, and the contents of superoxidase dismutase, glutathione peroxidase and catalase were significantly higher than those of CT group. After the 8-week treatment, the contents of serum neuron specific enolase, S100 calcium-binding protein B, heart-type fatty acid binding protein, malondialdehyde, advanced oxidation protein products, 8-hydroxy-2'-deoxyguanosine, monocyte chemoattractant protein-1,CD40, CD40 ligand, vascular endothelial cadherin, soluble intercellular adhesion molecule 1 and soluble vascular adhesion molecule 1 in patients ofTCMA group were all significantly lower than those of CT group and the contents of superoxidase dismutase, glutathione peroxidase and catalase were significantly higher than those of CT group. <br> Conclusions: Adjuvant

关 键 词：ISCHEMIC STROKE Salviae miltiorrhizae and LIGUSTRAZINE Neural function OXIDATIVE stress reaction Chemotactic factor Adhesion MOLECULE 

分 类 号：R73[医药卫生—肿瘤]