Comparison of the effects of oxycodone and fentanyl PCIA on postoperative pain, immune response and stress response in patients with cervical cancer  

作　　者：Hao-Lin Qu 

机构地区：[1]Anesthesiology Department,Jiangmen Central Hospital in Guangdong Province,Jiangmen,Guangdong Province

出　　处：《Journal of Hainan Medical University》2019年第9期58-61,共4页海南医学院学报（英文版）

摘　　要：Objective: To compare the effects of oxycodone and fentanyl patient-controlled intravenous analgesia (PCIA) on postoperative pain, immune response and stress response in patients with cervical cancer. Methods: 110 patients with early cervical cancer who received radical hysterectomy in our hospital between January 2017 and January 2019 were divided into the control group (n=55) and the study group (n=55) by random number table method. Control group received postoperative fentanyl PCIA, and study group received postoperative oxycodone PCIA. The differences in visual analogue scale (VAS) as well as serum contents of pain mediators (5-hydroxytryptamine, substance P and prostaglandin), Th1/Th2 cytokines (interleukin-2, tumor necrosis factor β, interleukin-5 and interleukin-13) and stress hormones (cortisol, norepinephrine, angiotensin 1 and angiotensin 2) after surgery and 24 h after surgery were compared between the two groups immediately. Results: Immediately after surgery, there was no statistically significant difference in VAS as well as serum contents of pain mediators, Th1/Th2 cytokines and stress hormones between the two groups. Twenty-four after the surgery, the VAS of the study group was lower than that of the control group;serum levels of 5-hydroxytryptamine, substance P and prostaglandin were lower than those of the control group as well;serum levels of interleukin-2 and tumor necrosis factor βwere lower than those of the control group while the levels of interleukin-5 and interleukin-13 were higher than those of the control group;serum levels of cortisol, norepinephrine, angiotensin 1 and angiotensin 2 were lower than those of the control group. Conclusion: Compared with conventional fentanyl PCIA, oxycodone PCIA after cervical cancer surgery has more advantages in analgesia and homeostasis.

关 键 词：Essential hypertension ECG Cornell voltage Left VENTRICLE HYPERTROPHY 

分 类 号：R73[医药卫生—肿瘤]