Effects of doxofylline combined with Dingzhang Decoction on AECOPD and its influence on NLRP3 mRNA and TLR4-MyD88 pathway  

作　　者：Ke Wang Qiong-Fen Wang Xi Li 

机构地区：[1]Department of Integrated Traditional Chinese and Western Medicine,the First Affiliated Hospital of Chengdu Medical College,Chengdu,Sichuan Province,610500,China

出　　处：《Journal of Hainan Medical University》2019年第3期22-26,共5页海南医学院学报（英文版）

摘　　要：Objective: To investigate the effect of doxofylline combined with Dingzhang Decoction on acute exacerbation of chronic obstructive pulmonary disease (AECOPD) and its effect on NLRP3 mRNA and TLR4MyD88 pathway. Methods: 120 patients with AECOPD from May 2017 to June 2018 were randomly divided into two groups (n=60). The control group was treated with doxofylline, and the observation group was treated with Dingzhang Tangdingzhang in the control group. Blood gas index and lung function index were compared between the two groups. Serum interleukin-1 (IL-1), interleukin-18 (IL-18) and peripheral blood lymphocyte NLRP3 mRNA and TLR4MyD88 pathway were detected and compared. Protein expression level. Results: The effective rate of the observation group was significantly higher than that of the control group (P<0.05). After treatment, the blood gas indexes of both groups were significantly improved (P<0.05). PaO2 in the observation group was higher than that in the control group and PaCO2 was significantly lower than the control group (P<0.05). After treatment, the lung function indexes of both groups were significantly increased (P<0.05). FEV1 and PEF in the observation group were significantly higher than the control group (P<0.05). After treatment, IL-1 and IL-18 were significantly decreased (P<0.05). IL-1 and IL-18 in the observation group were significantly lower than the control group (P<0.05). There was no significant difference in NLRP3 mRNA levels between the two groups before treatment (P>0.05), and it was significantly decreased after treatment (P<0.05). The level of NLRP3 mRNA in peripheral blood lymphocytes of the observation group was significantly lower than that of the control group (P<0.05). There was no significant difference in TLR4 and MyD88 protein levels between the two groups before treatment (P>0.05), and significantly decreased after treatment (P<0.05). The levels of TLR4 and MyD88 in peripheral blood lymphocytes of the observation group were significantly lower than those of the control group (P<

关 键 词：CHRONIC OBSTRUCTIVE PULMONARY DISEASE Acute exacerbation of CHRONIC OBSTRUCTIVE PULMONARY DISEASE DOXOFYLLINE Dingzhang DECOCTION NOD-like receptors protein 3 

分 类 号：R5[医药卫生—内科学]