Effects of lipoic acid on the activities of fibrinase, antioxidant enzymes and related factors in patients with type 2 diabetic foot  

作　　者：Han-Lin Yin Xiao-Xi Wang Yan Wang 

机构地区：[1]Department of endocrine metabolism and geriatrics,Deyang People's Hospital of Sichuan,Sichuan,Deyang,618000,China

出　　处：《Journal of Hainan Medical University》2018年第23期16-19,共4页海南医学院学报（英文版）

摘　　要：Objective:To investigate the effects of lipoic acid on the activities of fibrinase, antioxidant enzymes and related factors in patients with type 2 diabetic foot.Methods: 120 patients with type 2 diabetic foot treated in the Department of Endocrinology and Metabolism in our hospital from March 2015 to March 2018 were collected and randomly divided into control group and observation group, 60 cases in each group. The patients in control group were treated with alprostadil, and the patients in observation group were treated with lipoic acid combined with alprostadil. Before and after treatment, the levels of plasminogen activator, fibrinopeptide A, plasminogen activator inhibitor-1, superoxide dismutase (SOD), glutathione peroxidase (GSH-PX), catalase (CAT), Toll-like receptor 2 (TLR2), Toll-like receptor 9 (TLR9), vascular cell adhesion molecule-1 (VCAM-1), matrix metalloproteinase-9 (MMP-9) and homocysteine (Hcy) of patients in the two groups were detected and compared.Results: After treatment, the levels of plasminogen activator, SOD, GSH-PX and CAT of patients in the control group and the observation group were significantly increased. The levels of fibrinogen A and plasminogen activator inhibitor -1 of patients in the control group and the observation group were significantly decreased. The changes of the above indexes of patients in the observation group were more obvious than those in the control group (P<0.05). The levels of TLR2, TLR9, VCAM-1, MMP-9 and Hcy in the serum of patients in the control group and the observation group were significantly decreased. The down-regulation of these factors of patients in the observation group was more obvious than that in the control group (P<0.05).Conclusion:Lipoic acid combined with alprostadil in the treatment of type 2 diabetes mellitus disease can significantly enhance the activity of fibrinolytic enzymes and antioxidant capacity, alleviate inflammation, and it has a good clinical effect.

关 键 词：Lipoic acid ALPROSTADIL TYPE 2 diabetic foot CELLULASE Antioxidant enzyme 

分 类 号：R73[医药卫生—肿瘤]