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Apple polyphenol phloretin inhibits typeⅡglucose transporter and enhances anti-HER2 antibody drug binding as an adjuvant treatment for HER2-positive breast cancer
《Food Science and Human Wellness》2025年第4期1264-1280,共17页Han-Sheng Chang Tzu-Chun Cheng Shih-Hsin Tu Pei-Han Liao Yu-Ching Lee Chi-Tang Ho Min-Hsiung Pan Li-Ching Chen Yuan-Soon Ho 
supported by the Science and Technology Council,Taiwan,China(NSTC 112-2320-B-039-057 and MOST 111-2320-B-039-067-MY3);the China Medical University,Taiwan,China(CMU112-S-18),awarded to Yuan-Soon Ho;the China Medical University,Taiwan,China(CMU112-N-02),awarded to Li-Ching Chen;the Science and Technology Council,Taiwan,China(MOST 110-2320B-039-079)。
This study presents novel findings on the potential of phloretin,an apple polyphenol,to enhance the effectiveness of anti-human epidermal growth factor receptor-2(HER2)antibody therapy in HER2-positive breast cancer p...
关键词：TypeⅡglucose transporter(GLUT2) PHLORETIN Human epidermal growth factor receptor 2-intracellular domain(HER2-ICD) TRASTUZUMAB Trastuzumab-resistance 
Therapeutic potential of exercise-hormone irisin in Alzheimer's disease
《Neural Regeneration Research》2025年第6期1555-1564,共10页Eunhee Kim Rudolph ETanzi Se Hoon Choi 
supported by Cure Alzheimer’s Fund (to RET and SHC);JPB Foundation (to RET),and R56AG072054 (to SHC)。
Irisin is a myokine that is generated by cleavage of the membrane protein fibronectin type Ⅲ domain-containing protein 5(FNDC5) in response to physical exercise. Studies reveal that irisin/FNDC5 has neuroprotective f...
关键词：Alzheimer's disease EXERCISE fibronectin typeⅢdomain-containing protein 5(FNDC5) irisin 
Uniqueness and Nondegeneracy of Positive Solutions of General Kirchhoff Type Equations
《Acta Mathematicae Applicatae Sinica》2025年第2期414-424,共11页Yu-ting KANG Peng LUO Chang-lin XIANG Xue-xiu ZHONG 
partially supported by National Natural Science Foundation of China(Nos.12171183,11831009);the Fundamental Research Funds for the Central Universities(Nos.KJ02072020-0319,CCNU22LJ002);financially supported by National Natural Science Foundation of China(No.12271296);partially supported by National Natural Science Foundation of China(No.11801581);Guangdong Basic and Applied Basic Research Foundation(2021A1515010034);Guangzhou Basic and Applied Basic Research Foundation(202102020225);Province Natural Science Fund of Guangdong(2018A030310082).
In the present paper,we study uniqueness and nondegeneracy of positive solutions to the general Kirchhoff type equations-M(∫_(R^(N))|∇_(v)|^(2)dx)Δ^(v)=g(v)in R^(N);where M:[0;+∞)→R is a continuous function satisf...
关键词：Kirchhoff type equations general nonlinearities UNIQUENESS NONDEGENERACY singular perturbation problem 
Quantum Fisher information of a◇-type fourlevel atom interacting with a single-mode quantized field in an optomechanical cavity
《Communications in Theoretical Physics》2025年第4期55-64,共10页Fatemeh Daneshmand Hamid Reza Baghshahi Sayyed Yahya Mirafzali 
In science and technology,precision measurement of physical quantities is crucial,and the quantum Fisher information(QFI)plays a significant role in the study of quantum systems.In this work,we explore the dynamics of...
关键词：quantum fisher information multi-photon transition ◇-type four-level atom optomechanical cavity DISSIPATION 
Comprehensive impact of PPARG mutations in familial partial lipodystrophy type 3:Diagnosis,therapeutic strategies
《World Journal of Diabetes》2025年第4期310-313,共4页Heng-Li Lai Liu Yang 
This article reviews a paper in the World Journal of Diabetes.The study uncovers the link between PPARG gene mutations and metabolic disorders,such as insulin resistance,diabetes,and hypertriglyceridemia,and emphasize...
关键词：Familial partial lipodystrophy type 3 Genetic testing Metabolic disorders Personalized treatment 
Commentary on“Association of accelerometer-measured sleep duration and different intensities of physical activity with incident type 2 diabetes in a population-based cohort study”
《Journal of Sport and Health Science》2025年第2期75-76,共2页Barbara E.Ainsworth Haili Tian 
Type 2 diabetes(T2D)is a global public health issue.In 2021,537 million adults were diagnosed with T2D,corresponding to 10.5%of adults aged 20 and older.^(1)T2D increases the risks for morbidity,disability,and prematu...
关键词：public health issue population based cohort study ACCELEROMETER physical activity type diabetes t d preventing obesity sleep duration type diabetes 
Importance of early detection in multiple endocrine neoplasia type 1: Clinical insights and future directions
《World Journal of Gastrointestinal Oncology》2025年第4期1-7,共7页Mei-Jing Ren Zi-Li Zhang Can Tian Gui-Qiu Liu Chuan-Shan Zhang Hai-Bo Yu Qi Xin 
Tianjin Third Central Hospital,No.2019YNR3.
Multiple endocrine neoplasia type 1(MEN1)is an autosomal-inherited syndrome involving multiple endocrine tumors.It is characterized by multiple mutations in the tumor suppressor gene MEN1,which is located on chromosom...
关键词：Multiple endocrine neoplasia type 1 DIAGNOSIS Treatment Primary hyperparathyroidism Pancreatic neuroendocrine neoplasms 
MOUNTAIN-PASS SOLUTION FOR A KIRCHHOFF TYPE ELLIPTIC EQUATION
《Acta Mathematica Scientia》2025年第2期385-400,共16页Lifu WENG Xu ZHANG Huansong ZHOU 
supported by the NSFC(11931012,11871387,12371118)。
We are concerned with a nonlinear elliptic equation,involving a Kirchhoff type nonlocal term and a potential V(x),onℝ3.As is well known that,even in,H_(r)^(1)(R^(3)),the nonlinear term is a pure power form of∣u∣^(p−...
关键词：elliptic equation ground state mountain-pass solution Kirchhoff equation 
Centromere protein A knockdown inhibits rectal cancer through O6- methylguanine DNA methyltransferase/protein tyrosine phosphatase nonreceptor type 4 axis
《World Journal of Gastrointestinal Oncology》2025年第4期347-364,共18页Ming-Jie Xin Yong Yuan 
This study was reviewed and approved by the Ethic Committee of Medical College of Henan Vocational University of Science and Technology(Approval No.HVUYL414101416920231017001);all participants signed a written informed consent.
BACKGROUND Centromere protein A(CENPA)exhibits an increased expression level in primary human rectal cancer tissues,but its role has not been investigated.AIM To clarify the specific role and mechanism of CENPA in rec...
关键词：Rectal cancer Centromere protein A O6-methylguanine DNA methyltransferase Protein tyrosine phosphatase nonreceptor type 4 PROLIFERATION INVASION 
Herglotz type Noether theorems of nonholonomic systems with generalized fractional derivatives
《Theoretical & Applied Mechanics Letters》2025年第2期179-187,共9页Yuan-Yuan Deng Yi Zhang 
supported by the National Natural Science Foundation of China(Grant No.12272248);the Postgraduate Research and Practice Innovation Program of Jiangsu Province of China(Grant No.KYCX23_3296).
Fractional calculus is widely used to deal with nonconservative dynamics because of its memorability and non-local properties.In this paper,the Herglotz principle with generalized operators is discussed,and the Herglo...
关键词：Nonholonomic system Herglotz principle Noether theorem Generalized operators 
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