PHLORETIN

作品数:13被引量:8H指数:2
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相关领域:医药卫生更多>>
相关作者:李源朱晓彤啜玉彩束刚王松波更多>>
相关机构:华南农业大学第四军医大学第四军医大学西京医院第二军医大学更多>>
相关期刊:《Engineering》《中国老年学杂志》《Food Bioscience》《Food Science and Human Wellness》更多>>
相关基金:国家自然科学基金陕西省自然科学基金中国博士后科学基金更多>>
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Apple polyphenol phloretin inhibits typeⅡglucose transporter and enhances anti-HER2 antibody drug binding as an adjuvant treatment for HER2-positive breast cancer
《Food Science and Human Wellness》2025年第4期1264-1280,共17页Han-Sheng Chang Tzu-Chun Cheng Shih-Hsin Tu Pei-Han Liao Yu-Ching Lee Chi-Tang Ho Min-Hsiung Pan Li-Ching Chen Yuan-Soon Ho 
supported by the Science and Technology Council,Taiwan,China(NSTC 112-2320-B-039-057 and MOST 111-2320-B-039-067-MY3);the China Medical University,Taiwan,China(CMU112-S-18),awarded to Yuan-Soon Ho;the China Medical University,Taiwan,China(CMU112-N-02),awarded to Li-Ching Chen;the Science and Technology Council,Taiwan,China(MOST 110-2320B-039-079)。
This study presents novel findings on the potential of phloretin,an apple polyphenol,to enhance the effectiveness of anti-human epidermal growth factor receptor-2(HER2)antibody therapy in HER2-positive breast cancer p...
关键词:TypeⅡglucose transporter(GLUT2) PHLORETIN Human epidermal growth factor receptor 2-intracellular domain(HER2-ICD) TRASTUZUMAB Trastuzumab-resistance 
Phloretin Targets Polyphosphate Kinase 1 to Attenuate Acinetobacter baumannii Virulence and Persistence In Vitro and In Vivo
《Engineering》2024年第12期258-271,共14页Hongfa Lv Shufang Li Jian Guan Peng Zhang Lingcong Kong Hongxia Ma Dan Li Xuming Deng Xiaodi Niu Jianfeng Wang 
supported by the National Natural Science Foundation of China(U23A20242 and U22A20523);the Fundamental Research Funds for the Central Universities under Grant 2023JCXK-01。
Acinetobacter baumannii(A.baumannii)is well known for its virulence and persistence,particularly in intensive care units.Therefore,new strategies and candidates to treat A.baumannii infection are urgently needed consi...
关键词:Acinetobacter baumannii VIRULENCE PERSISTENCE PHLORETIN Polyphosphate kinase 
A carbon-carbon hydrolase from human gut probiotics Flavonifractor plautii catalyzes phloretin conversion
《Food Bioscience》2022年第6期2000-2008,共9页Ting Yuan Qiu Tian Gong Shuai Zhang Qi Hang Chen Ching Yuan Hu Yong Hong Meng 
supported by the National Natural Science Foundation(31972089);the 2020 Team Innovation Project from the Fundamental Scientific Research Special Capital Fund of the National Universities,China(GK202001008).
Although the catabolic pathway of some flavonoids in the human colon has been elucidated,knowledge of related gut microbes and responsible enzymes is still limited.In this study,a phloretin hydrolase gene(phy)from Fla...
关键词:Phloretin hydrolase Flavonifractor plautii Gut microbe 
Supramolecular Architectures of 2-(3-(4-acetoxyphenyl)propanoyl)benzene-1,3,5-triyl triacetate (1) and 4-(3-(4-acetoxyphenyl)propanoyl)-5-hydroxy-1,3-phenylene diacetate (2)
《International Journal of Organic Chemistry》2022年第4期200-207,共8页Li Wang Rui Xu 
2-(3-(4-acetoxyphenyl)propanoyl)benzene-1,3,5-triyl triacetate (1), C25H22O9 and 4-(3-(4-acetoxyphenyl)propanoyl)-5-hydroxy-1,3-phenylene diacetate (2), C21H20O
关键词:Phloretin Derivatives Crystal Structure Hydrogen Bonds 
Phloretin-induced suppression of oxidative and nitrosative stress attenuates doxorubicin-induced cardiotoxicity in rats被引量:2
《Asian Pacific Journal of Tropical Biomedicine》2022年第3期124-131,共8页Shivani S.Wagh Kalpesh R.Patil Umesh B.Mahajan Pradnya D.Bagal Avinash R.Wadkar Basavraj Bommanhalli Prabhakar R.Patil Sameer N.Goyal Shreesh Ojha Chandragouda R.Patil 
Objective:To compare the cardioprotective efficacy of equimolar doses(50 mM/kg,p.o.)of phloretin and genistein against doxorubicin-induced cardiotoxicity in rats.Methods:Cardiotoxicity was induced in rats by intraperi...
关键词:CARDIOTOXICITY CHEMOPREVENTION DOXORUBICIN Genistein PHLORETIN PHYTOESTROGENS Cardiac injury Hemodynamic changes 
Raising the production of phloretin by alleviation of by-product of chalcone synthase in the engineered yeast被引量:5
《Science China(Life Sciences)》2020年第11期1734-1743,共10页Chunmei Jiang Xiaonan Liu Xianqing Chen Yi Cai Yibin Zhuang Tian Liu Xiaoxi Zhu Hui Wang Yuwan Liu Huifeng Jiang Wen Wang 
financially supported by Talents Team Construction Fund of Northwestern Polytechnical University (NWPU);the National Natural Science Foundation of China (31701722);the China Postdoctoral Science Foundation (2017M620471);the National Natural Science Foundation of China (31901026)。
Phloretin is an important skin-lightening and depigmenting agent from the peel of apples. Although de novo production of phloretin has been realized in microbes using the natural pathway from plants, the efficiency of...
关键词:PHLORETIN Saccharomyces cerevisiae metabolic engineering microbial cell factories fed-batch fermentation 
Aquaglyceroporins but not orthodox aquaporins are involved in the cryotolerance of pig spermatozoa
《Journal of Animal Science and Biotechnology》2020年第1期20-31,共12页Ariadna Delgado-Bermúdez Marc Llavanera Leira Fernández-Bastit Sandra Recuero Yentel Mateo-Otero Sergi Bonet Isabel Barranco Beatriz Fernández-Fuertes Marc Yeste 
the European Commission(H2020-MSCA-IF-79212);the Ministry of Science,Innovation and Universities,Spain(Grants:RYC-2014-15581,AGL2016–81890-REDT,AGL2017–88329-R and FJCI-2017-31689);the Regional Government of Catalonia,Spain(2017-SGR-1229).
Background:Aquaporins(AQPs)are a family of transmembrane water channels that includes orthodox AQPs,aquaglyceroporins(GLPs)and super AQPs.AQP3,AQP7,AQP9 and AQP11 have been identified in boar sperm,and they are crucia...
关键词:ACETAZOLAMIDE AQUAPORINS Boar PHLORETIN PROPANEDIOL Sperm 
In Vitro Antioxidant Properties of Phloretin—An Important Phytocompound
《Journal of Biosciences and Medicines》2016年第1期85-94,共10页Tamilarasan Nithiya Rajangam Udayakumar 
Reactive oxygen species [ROS] cause oxidative damage to the tissues and protection from such damages is provided by endogenous and exogenous antioxidants. Much research work has been carried out in recent years on the...
关键词:Antioxidant Activity In Vitro PHLORETIN DPPH Free Radicals 
Phloretin对猪肌内与皮下脂肪前体细胞分化与相关基因表达的影响
《畜牧与兽医》2012年第S1期166-167,共2页陆乃升 束刚 王松波 王丽娜 朱晓彤 高萍 江青艳 
根皮素(phloretin)是一类普遍存在于果皮及根茎中的黄酮类物质,具有抗氧化、清除自由基、抑制糖及长链脂肪酸的转运等多种生物学活性,但目前有关根皮素对脂肪细胞分化的调控作用鲜见报道。为此,本试验采用胶原酶消化法分离培养了仔猪背...
关键词:肌内脂肪 前体细胞 根皮素 PHLORETIN 基因表达 胶原酶消化法 脂肪细胞分化 诱导分化 分离培养 长链脂肪酸 
Phloretin对Aβ_(25-35)诱导PC12细胞凋亡的影响及其机制
《第四军医大学学报》2008年第14期1256-1258,共3页啜玉彩 李源 胡玉珍 司瑞 黄春霞 龚卫琴 
陕西省自然科学基金(2006C212)
目的:探讨Aβ25-35(β-amyloid)诱导PC12细胞凋亡过程中氯通道阻断剂Phloretin的保护作用及其机制.方法:采用MTT比色,LDH(lactate dehydrogenase)活力检测、Hoechst33258染色和琼脂糖凝胶电泳比较正常对照组、Aβ25-35损伤组和Aβ25-35+...
关键词:Β淀粉样蛋白 凋亡 JNK PHLORETIN 
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