Bioinformatic approaches of liquid-liquid phase separation in human disease  

作　　者：Jun Sun Yilong Chen Ruiye Bi Yong Yuan Haopeng Yu 

机构地区：[1]Department of Thoracic Surgery and West China Biomedical Big Data Center,West China Hospital,Sichuan University,Chengdu,Sichuan 610041,China [2]Med-X Center for Informatics,Sichuan University,Chengdu,Sichuan 610041,China [3]Department of Orthognathic and TMJ Surgery,State Key Laboratory of Oral Diseases,National Clinical Research Center for Oral Diseases,West China Hospital of Stomatology,Sichuan University,Chengdu,Sichuan 610041,China

出　　处：《Chinese Medical Journal》2024年第16期1912-1925,共14页中华医学杂志（英文版）

基　　金：funded by grants from the Natural Science Foundation of Guangdong Province,China(No.2023A1515010148);the Postdoctoral Fellowship Program of CPSF(No.GZC20241143);the China Postdoctoral Science Foundation(No.2024M752202);the National Natural Youth Science Foundation of China(No.32100927);the National Natural Science Foundation of China(No.81970481).

摘　　要：Biomolecular aggregation within cellular environments via liquid-liquid phase separation(LLPS)spontaneously forms droplet-like structures,which play pivotal roles in diverse biological processes.These structures are closely associated with a range of diseases,including neurodegenerative disorders,cancer and infectious diseases,highlighting the significance of understanding LLPS mechanisms for elucidating disease pathogenesis,and exploring potential therapeutic interventions.In this review,we delineate recent advancements in LLPS research,emphasizing its pathological relevance,therapeutic considerations,and the pivotal role of bioinformatic tools and databases in facilitating LLPS investigations.Additionally,we undertook a comprehensive analysis of bioinformatic resources dedicated to LLPS research in order to elucidate their functionality and applicability.By providing comprehensive insights into current LLPS-related bioinformatics resources,this review highlights its implications for human health and disease.

关 键 词：Phase separation Liquid-liquid phase separation DISEASE Phase separation databases Bioinformatic tools 

分 类 号：R363[医药卫生—病理学]