Cuproptosis:A potential therapeutic target in clear cell renal cell carcinoma  

作　　者：Yuetong Zhao Jie Li Xiaojie Lu Shuang Wu Yunze Xing Yaxuan Fang Bo Yang 

机构地区：[1]Department of Nephrology,First Teaching Hospital of Tianjin University of Traditional Chinese Medicine,Tianjin 300381,China [2]Department of Nephrology,National Clinical Research Center for Chinese Medicine Acupuncture and Moxibustion,Tianjin 300381,China

出　　处：《Chinese Medical Journal》2024年第11期1378-1380,共3页中华医学杂志（英文版）

摘　　要：To the Editor:Copper is a crucial trace element in the body that plays a key role in metabolism and biological functions.Copper ions are found in two forms,Cu^(1+)and Cu^(2+),of which Cu^(1+)is the main form stored in cells.Numerous studies have shown that intracellular copper accumulation can cause oxidative stress and disrupt cellular function.[1]Different from apoptosis,autophagy,pyroptosis,and ferroptosis,cuproptosis is a newly discovered type of cell death in 2022.[2]It is mediated by protein lipoylation with ferredoxin 1(FDX1)in mitochondria.The most common pathological type of kidney cancer in adults is clear cell renal cell carcinoma(ccRCC),which accounts for 70-80%of all cases of renal cell carcinoma(RCC).[3]Currently,surgical resection is the preferred treatment for RCC,as radiotherapy,chemotherapy,and immunotherapy have shown limited effectiveness in treating ccRCC.However,cuproptosis induction may offer a new approach for ccRCC treatment.

关 键 词：METABOLISM CHEMOTHERAPY POTENTIAL 

分 类 号：R737.11[医药卫生—肿瘤]