The role of acute normovolemic hemodilution in reducing allogeneic blood transfusion in glioblastoma surgery:a case-control study  

作　　者：Ping Chen Xin‑Huang Zhang Ying Wang Xian‑Zhong Lin De‑Zhi Kang Qing‑Song Lin 

机构地区：[1]Department of Anesthesiology,The First Affiliated Hospital of Fujian Medical University,Fuzhou 350005,Fujian,China [2]Department of Neurosurgery,The First Affiliated Hospital of Fujian Medical University,No.20 Chazhong Rd,Taijiang District,Fuzhou 350005,Fujian,China [3]Department of Neurosurgery,Binhai Branch of National Regional Medical Center,The First Affiliated Hospital of Fujian Medical University,Fuzhou 350209,Fujian,China [4]Fujian Provincial Institutes of Brain Disorders and Brain Sciences,The First Affiliated Hospital of Fujian Medical University,Fuzhou 350005,Fujian,China [5]Fujian Provincial Clinical Research Center for Neurological Diseases,The First Affiliated Hospital of Fujian Medical University,Fuzhou 350005,Fujian,China [6]Fujian Provincial Key Laboratory of Precision Medicine for Cancer,The First Affiliated Hospital of Fujian Medical University,Fuzhou 350005,Fujian,China

出　　处：《Chinese Neurosurgical Journal》2024年第1期35-41,共7页中华神经外科杂志（英文）

基　　金：Fujian Provincial Health Technology Project(No.2021GGA031 to Qing-Song Lin);Natural Science Foundation of Fujian Province(No.2021J05148 to Qing-Song Lin);Fujian Provincial Finance Project(No.BPB-LQS2021 to Qing-Song Lin);Nature Science Foundation of Fujian province(No.2022J01678 to Ping Chen);Project to improve the diagnosis and treatment of intractable diseases of the cerebrovascular and nervous system(No.PT-YNBZW2018)

摘　　要：Background Acute normovolemic hemodilution(ANH)was first introduced in glioblastoma surgery,and its role in reducing allogeneic blood transfusion was investigated in this study.Methods This study enrolled supratentorial glioblastoma patients who received total resection.In the ANH group,the patients were required to draw blood before the operation,and the blood will be transfused back to the patient during the operation.The association between ANH and clinical features was investigated.Results Sixty supratentorial glioblastoma patients were enrolled in this study,25 patients were allocated in the ANH group,and another 35 patients were included in the control group.ANH dramatically reduced the need for allogeneic blood transfusion(3[12%]vs 12[34.3%],P=0.049),and the blood transfusion per total of patients was dramatically decreased by the application of ANH(0.40±1.15 units vs 1.06±1.59 units,P=0.069).Furthermore,ANH also markedly reduced the requirement of fresh frozen plasma(FFP)transfusion(2[8%]vs 11[31.4%],P=0.030)and the volume of FFP transfusion per total of patients(32.00±114.46 mL vs 115.71±181.00 mL,P=0.033).The complication rate was similar between the two groups.Conclusions ANH was a safe and effective blood conservation technique in glioblastoma surgery.

关 键 词：GLIOBLASTOMA Acute normovolemic hemodilution SURGERY Blood transfusion 

分 类 号：R739.4[医药卫生—肿瘤]