The clinical,radiological,and surgical characteristics of anterior perforated substance glioma:a retrospective study  

作　　者：Zhiliang Wang Lianwang Li Zheng Wang Xuzhu Chen Zhong Zhang 

机构地区：[1]Department of Neurosurgery,Beijing Tiantan Hospital,Capital Medical University,No.119 South 4th Ring West Road,Beijing 100070,People’s Republic of China [2]Department of Molecular Neuropathology,Beijing Neurosurgical Institute,Capital Medical University,Beijing,China [3]Department of Radiology,Beijing Neurosurgical Institute,Capital Medical University,Beijing,China [4]Department of Radiology,Beijing Tiantan Hospital,Capital Medical University,No.119 South 4th Ring West Road,Beijing 100070,People’s Republic of China

出　　处：《Chinese Neurosurgical Journal》2024年第1期28-34,共7页中华神经外科杂志（英文）

基　　金：funding by the National Natural Science Foundation of China(No.81772005,No.82102764);the collaborative innovative major special project supported by Beijing Municipal Science&Technology Commission(No.Z191100006619088)

摘　　要：Background To explore the clinical,radiological,and surgical characteristics of anterior perforated substance(APS)gliomas.Methods Twenty patients with APS glioma who were treated with surgery between March 2019 and January 2022 from Tiantan hospital were retrospectively reviewed.The clinical,histological and radiological data were collected.Results Twenty patients,including 7 males(55%)and 13 females(45%),with a mean age at diagnosis of 37.9 years(range,28-53 years)underwent operative intervention for APS.Headaches and dizziness were the most common preoperative symptoms in the majority patients(14,70%).Based on radiological features of MRI,the APS was classified into two subtypes,type A and type B.Seven patients(40%)in type A indicated a clear tumor margin,while 13 patients(60%)in type B showed an ill-defined margin.The surgical approach including frontal,temporal,and coronal frontal incisions for type A and type B tumors,respectively.Three patients in type A received total resection,while one patient in type B were total resected.Pathologically,12 cases(60%,12/20)were diagnosed as astrocytoma and 8 cases(20%,8/20)were oligodendroglioma.Meanwhile,17 cases(85%,17/20)had MGMT promotor methylation.Conclusion In this study,we performed the first systematic research of patients with APS glioma.Most of patients with APS presented headaches and dizziness symptoms.The APS glioma was further divided into two major radiological subtypes with relevant different surgical approaches.The APS glioma in type A were more likely to receive total resection.

关 键 词：Anterior perforated substance GLIOMA Magnetic resonance imaging Operation 

分 类 号：R739.4[医药卫生—肿瘤]