Cytomegalovirus antigen-specific T cell immune responses in patients with autoimmune diseases under different cytomegalovirus infection status  

作　　者：Yuting Tan Huimin Ma Xiaoqing Liu Xiaochun Shi Wenjie Zheng Jingtao Cui Lifan Zhang Yaling Dou Baotong Zhou 

机构地区：[1]Department of Infectious Diseases,Peking Union Medical College Hospital,Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing 100730,China [2]Center for Tuberculosis Research,Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing 100730,China [3]Clinical Epidemiology Unit,Peking Union Medical College,International Clinical Epidemiology Network,Beijing 100730,China [4]Peking Union Medical College Hospitals Center for the Research of Translational Medicine,Beijing 100730,China [5]Department of Infectious Diseases,State Key Laboratory of Complex Severe and Rare Disease,Peking Union Medical College Hospital,Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing 100730,China [6]Department of Rheumatology and Clinical Immunology,Key Laboratory of Rheumatology and Clinical Immunology,Peking Union Medical College Hospital,Peking Union Medical College and Chinese Academy of Medical Sciences,Beijing 100730,China [7]Department of Clinical Laboratories,Peking Union Medical College Hospital,Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing 100730,China

出　　处：《Chinese Medical Journal》2023年第19期2386-2388,共3页中华医学杂志（英文版）

摘　　要：To the Editor:Patients with autoimmune diseases have increased risk of active cytomegalovirus(CMV)infection due to immune dysfunction or the application of glucocorticoid and immunosuppressants.[1]Cui et al[2]found that compared with human immunodeficiency virus(HIV)/acquired immune deficiency syndrome(27%),posttransplant patients(14.8%),and hematological malignancies(5.1%),patients with autoimmune disease had the highest incidence of CMV antigenemia(35.1%).Monitoring CMV antigen-specific T cell immunity is helpful for understanding the protective immunity against CMV infection and identifing the risk of CMV-related complications.Currently,the CMV antigen-specific T cell immune responses in patients with autoimmune diseases remains unknown.

关 键 词：IMMUNITY PATIENTS AUTOIMMUNE 

分 类 号：R511[医药卫生—内科学]