Role of adipokines in sarcopenia  

作　　者：Wenhao Lu Wenjie Feng Jieyu Lai Dongliang Yuan Wenfeng Xiao Yusheng Li 

机构地区：[1]Department of Orthopaedics,Xiangya Hospital,Central South University,Changsha,Hunan 410008,China [2]National Clinical Research Center for Geriatric Disorders,Xiangya Hospital,Central South University,Changsha,Hunan 410008,China [3]Department of Burns and Plastic Surgery,Xiangya Hospital,Central South University,Changsha,Hunan 410008,China [4]Xiangya School of Medicine,Central South University,Changsha,Hunan 410083,China.

出　　处：《Chinese Medical Journal》2023年第15期1794-1804,共11页中华医学杂志（英文版）

基　　金：National Natural Science Foundation of China(Nos.82272611,82072506);National Clinical Research Center for Geriatric Disorders(Nos.2021KFJJ02 and 2021LNJJ05);National Clinical Research Center for Orthopedics,Sports Medicine and Rehabilitation(No.2021-NCRC-CXJJ-PY-40);Science and Technology Innovation Program of Hunan Province(No.2021RC3025);Innovation-Driven Project of Central South university(No.2020CX045);Program of Health Commission of Hunan Province(202204074879);Independent Exploration and Innovation Project for Post-graduate Students of Central South University(No.2022ZZTS0906)

摘　　要：Sarcopenia is an age-related disease that mainly involves decreases in muscle mass,muscle strength and muscle function.At the same time,the body fat content increases with aging,especially the visceral fat content.Adipose tissue is an endocrine organ that secretes biologically active factors called adipokines,which act on local and distant tissues.Studies have revealed that some adipokines exert regulatory effects on muscle,such as higher serum leptin levels causing a decrease in muscle function and adiponectin inhibits the transcriptional activity of Forkhead box O3(FoxO3)by activating peroxisome proliferators-activated receptor-γcoactivator-1α(PGC-1α)and sensitizing cells to insulin,thereby repressing atrophy-related genes(atrogin-1 and muscle RING finger 1[MuRF1])to prevent the loss of muscle mass.Here,we describe the effects on muscle of adipokines produced by adipose tissue,such as leptin,adiponectin,resistin,mucin and lipocalin-2,and discuss the importance of these adipokines for understanding the development of sarcopenia.

关 键 词：SARCOPENIA ADIPOKINES Leptin ADIPONECTIN Lipocalin-2 VISFATIN RESISTIN 

分 类 号：R746.4[医药卫生—神经病学与精神病学]