Developmental origins of health and disease: Impact of paternal nutrition and lifestyle  

作　　者：Qiaoyu Shi Kemin Qi 

机构地区：[1]Laboratory of Nutrition and Development,Key Laboratory of Major Diseases in Children,Ministry of Education,Beijing Pediatric Research Institute,Beijing Children’s Hospital,Capital Medical University,National Center for Children’s Health,Beijing,China

出　　处：《Pediatric Investigation》2023年第2期111-131,共21页儿科学研究（英文）

基　　金：The Research Funds of Reform and Development Budget from Beijing Municipal Science and Technology Commission,Grant/Award Number:bjsekyjs to K.Q.

摘　　要：Most epidemiological and experimental studies have focused on maternal influences on offspring’s health.The impact of maternal undernutrition,overnutrition,hypoxia,and stress is linked to adverse offspring outcomes across a range of systems including cardiometabolic,respiratory,endocrine,and reproduction among others.During the past decade,it has become evident that paternal environmental factors are also linked to the development of diseases in offspring.In this article,we aim to outline the current understanding of the impact of male health and environmental exposure on offspring development,health,and disease and explore the mechanisms underlying the paternal programming of offspring health.The available evidence suggests that poor paternal pre-conceptional nutrition and lifestyle,and advanced age can increase the risk of negative outcomes in offspring,via both direct(genetic/epigenetic)and indirect(maternal uterine environment)effects.Beginning at preconception,and during utero and the early life after birth,cells acquire an epigenetic memory of the early exposure which can be influential across the entire lifespan and program a child’s health.Potentially not only mothers but also fathers should be advised that maintaining a healthy diet and lifestyle is important to improve offspring health as well as the parental health status.However,the evidence is mostly based on animal studies,and well-designed human studies are urgently needed to verify findings from animal data.

关 键 词：EPIGENETICS Mental health Metabolic outcomes OFFSPRING Paternal exposure Telomere length 

分 类 号：R179[医药卫生—妇幼卫生保健]