Metabolite alpha-ketoglutarate:a novel target of gasdermin C-dependent pyroptosis  

作　　者：Yao Zhang Wu Jian Lu He Jianhua Wu 

机构地区：[1]Department of Inspection,The First People’s Hospital of Changde City,Changde,Hunan 415003,China [2]Department of Neurosurgery,The First Affiliated Hospital of University of South China,Hengyang,Hunan 421001,China

出　　处：《Chinese Medical Journal》2023年第13期1630-1631,共2页中华医学杂志（英文版）

基　　金：National Natural Science Foundation of China(No.81803535);Natural Science Foundation of Hunan Province(No.2018JJ6070)

摘　　要：To the Editor:Tumors are one of the main causes of death worldwide.Pyroptosis is a newly discovered form of cell death,causing cell swelling and rapid lysis,which releases pro-inflammatory mediators and enhances the inflammatory response.[1]Inflammation increases the immune response to tumors and inhibits their progression.The ultimate goal of cancer therapeutics is to maximize the destruction of tumor cells while minimizing the damage to normal tissues.[2]Targeting pyroptosis of tumor cells could overcome the apoptotic resistance and trigger antitumor immunity,thus being a good treatment for tumors.

关 键 词：IMMUNITY DEATH damage 

分 类 号：R777.1[医药卫生—眼科]