Aripiprazole in the treatment of acute episode of schizophrenia: a real-world study in China  

作　　者：Qian Li Yun’ai Su Xuemei Liao Maosheng Fang Jianliang Gao Jia Xu Mingjun Duan Haiying Yu Yang Yang Zhiyu Chen Jintong Liu Shaoxiao Yan Peifen Yao Shuying Li Changhong Wang Bin Wu Congpei Zhang Tianmei Si 

机构地区：[1]Department of Psychopharmacology,Peking University Sixth Hospital(Institute of Mental Health),NHC Key Laboratory of Mental Health(Peking University),National Clinical Research Center for Mental Disorders(Peking University Sixth Hospital),Beijing 100191,China [2]Department of Psychiatry,Wuhan Mental Health Center,Wuhan,Hubei 430012,China [3]Department of Child and Adolescent Psychology,the Fourth People’s Hospital of Hefei,Hefei,Anhui 230022,China [4]Mental Health Center,the First Psychiatric Hospital of Harbin,Harbin,Heilongjiang 150056,China [5]Department of Science and Education,the Fourth People’s Hospital of Chengdu,Chengdu,Sichuan 610036,China [6]Department of Psychiatry,the Chinese People’s Liberation Army 904th Hospital,Changzhou,Jiangsu 213003,China [7]Department of Psychiatry,Beijing Anding Hospital,Beijing 100029,China [8]Department of Psychiatry,Hangzhou Seventh People’s Hospital,Hangzhou,Zhejiang 310063,China [9]Department of Adolescent and Child Psychological Behavior,Shandong Mental Health Center,Jinan,Shandong 250014,China [10]Department of Integrated Chinese and Western Medicine,Beijing Huilongguan Hospital,Beijing 102208,China [11]Department of Psychiatry,Shanghai Mental Health Center,Shanghai 201109,China [12]Department of Psychiatry,the First Affiliated Hospital of Zhengzhou University,Zhengzhou,Henan 450052,China [13]Department of Psychiatry,the Second Affiliated Hospital of Xinxiang Medical University,Xinxiang,Henan 456750,China [14]Department of Psychiatry,Xi’an Mental Health Center,Xi’an,Shaanxi 710067,China

出　　处：《Chinese Medical Journal》2023年第9期1126-1128,共3页中华医学杂志（英文版）

基　　金：Capital Medical Development Research Fund(No.2020-2-4113)

摘　　要：To the Editor:Schizophrenia is a progressive,debilitating disease.[1]Safe and effective treatment performed during the acute phase is the first step to improve prognosis,and it is critically important.Aripiprazole is known as a dopamine system stabilizer,and it exerts partial agonism with high affinity at dopamine D2 and serotonin-1A(5-HT1A)receptors as well as antagonism at serotonin-2A(5-HT2A)receptors.[2]It has been shown to be efficacious in amelioration of both positive and negative symptoms of acute schizophrenia,and it shows better tolerance than most antipsychotics.[3]We conducted a real-world study to further confirm the efficacy and safety of aripiprazole in patients with acute episodes of schizophrenia in China and tried to explore the clinical variables,including various drug regimens,which may be correlated with the efficacy of aripiprazole,and provide a basis for the optimization of aripiprazole treatment for patients with acute schizophrenia.

关 键 词：SCHIZOPHRENIA ACUTE DOPAMINE 

分 类 号：R749.3[医药卫生—神经病学与精神病学]