Expression profile of circRNA in biliary atresia and choledochal cyst  

作　　者：Wenjie Zhang Zhouguang Wu Siqi Chen Taoyan Zuo Zhen Cheng Jingru Fu Bin Wang 

机构地区：[1]Department of General Surgery,Shenzhen Children’s Hospital,Shenzhen,Guangdong 518000,China

出　　处：《Chinese Medical Journal》2023年第3期365-366,共2页中华医学杂志（英文版）

基　　金：supported by Sanming Project of Medicine in Shenzhen(No.SZSM201812055);National Natural Science Foundation of China(No.81770512);Research topic on academic and postgraduate education in China(No.2020MSA126).

摘　　要：To the Editor:Biliary atresia(BA)is a rare obliterative cholangiopathy that occurs during infancy in association with destructive liver inflammation and hepatic fibrosis.Although recent studies have shown that transforming growth factor-b(TGF-b)plays an important role in liver fibrosis and inflammation in BA,disease mechanisms remain poorly understood.Circular RNAs(circRNAs)are a recently discovered unique class of regulatory RNA molecules with high specificity.As previous evidence links circRNAs to the regulation of the TGF-b inflammatory signaling pathway,we further investigated the potential regulatory roles of circRNAs in BA and found novel insights into BA pathogenesis.

关 键 词：INFLAMMATION SPECIFICITY HEPATIC 

分 类 号：R575.7[医药卫生—消化系统]