Burden of epilepsy in China and its provinces,1990 to 2019:findings from the Global Burden of Disease Study 2019  

作　　者：Wei Liu Yangyang Xu Yicong Lin Lijun Wang Maigeng Zhou Peng Yin Guoguang Zhao 

机构地区：[1]National Center for Chronic and Non-Communicable Disease Control and Prevention,Chinese Center for Disease Control and Prevention,Beijing 100050,China [2]Department of Neurology,Xuanwu Hospital,Capital Medical University,National Center for Neurological Disorders,Beijing 100053,China [3]Department of Neurosurgery,Xuanwu Hospital,Capital Medical University,National Center for Neurological Disorders,Beijing 100053,China

出　　处：《Chinese Medical Journal》2023年第3期305-312,共8页中华医学杂志（英文版）

摘　　要：Background: Epilepsy accounts for a significant portion of the global disease burden. However, little is known about the disease burden of epilepsy in China and its provinces. Methods: We assessed the burden of epilepsy in China and its provinces, municipalities, and autonomous regions from 1990 to 2019. Burden was measured as incidence, prevalence, deaths, years lived with disability, years of life lost, and disability-adjusted life years (DALYs), by age, sex, year, and province. We used the Socio-Demographic Index (SDI) to determine the association between the provincial development level and age-standardized DALY rates of epilepsy from 1990 to 2019. Results: In 2019, epilepsy caused 1367.51 thousand (95% uncertainty interval [UI]: 979.92–1837.61 thousand) DALYs, and the age-standardized DALY rate was 99.77 (95% UI: 71.33–133.52)/100,000. The age-standardized incidence and prevalence rates for epilepsy in China were 24.65/100,000 and 219.69/100,000, increased by 45.00% (95% UI: 8.03–98.74%) and 35.72% (95% UI: 0.47–86.19%) compared with that in 1990, respectively. From 1990 to 2019, the proportion of DALY caused by epilepsy in the age group under 25 years steadily decreased. The proportion of DALYs caused by epilepsy in people aged 50 years and over increased from 9.45% and 10.22% in 1990 to 29.01% and 32.72% for male and female individuals in 2019, respectively. The highest age-standardized mortality rates were seen in Tibet (4.26 [95% UI: 1.43–5.66]/100,000), Qinghai (1.80 [95% UI: 1.15–2.36]/100,000), and Yunnan (1.30 [95% UI: 0.88–1.62]/100,000), and the lowest mortality rates were in Guangdong (0.48 [95% UI: 0.39–0.64]/100,000), Zhejiang (0.56 [95% UI: 0.44–0.70]/100,000), and Shanghai (0.57 [95% UI: 0.41–0.73]/100,000). The age-standardized DALY rates across the country and in provinces, municipalities, and autonomous regions generally decreased as their SDI increased. Conclusions: The disease burden of epilepsy is still heavy in China, especially in the western provinces. The incidenc

关 键 词：Aged EPILEPSY Global Burden of disease Quality-adjusted life years Disability-adjusted life years INCIDENCE Prevalence China 

分 类 号：R742.1[医药卫生—神经病学与精神病学]