Immunologically effective biomaterials-enhanced vaccines against infection of pathogenic microorganisms  

作　　者：Qi Wei Shixian Liu Xu Huang Hua Xin Jianxun Ding 

机构地区：[1]Key Laboratory of Polymer Ecomaterials,Changchun Institute of Applied Chemistry,Chinese Academy of Sciences,5625 Renmin Street,Changchun 130022,China [2]Department of Thoracic Surgery,China-Japan Union Hospital of Jilin University,126 Xiantai Street,Changchun 130033,China [3]Department of Orthopedics,The Second Hospital of Jilin University,218 Ziqiang Street,Changchun 130041,China

出　　处：《Biosafety and Health》2023年第1期45-61,共17页生物安全与健康（英文）

基　　金：the National Key Research and Development Program of China(Nos.2022YFC2603500/2022YFC2603501 and 2021YFC2400600/2021YFC2400603/2021YFC2400604);the National Natural Science Foundation of China(Nos.52273158,U21A2099,52022095,51973216,and 51873207);the Science and Technology Development Program of Jilin Province(Nos.20220204018YY,20210509005RQ,20210504001GH,and 20200404182YY);the Youth Innovation Promotion Association of Chinese Academy of Sciences(No.2019230);the Special Project for City–Academy Scientific and Technological Innovation Cooperation of Changchun(No.21SH14);the Fundamental Research Funds for the Central Universities,JLU.

摘　　要：Infectious diseases are severe public health events that threaten global health.Prophylactic vaccines have been considered as the most effective strategy to train the immune system to recognize and clear pathogenic infections.However,the existing vaccines against infectious diseases have several limitations,such as difficulties in mass manufacturing and storage,weak immunogenicity,and low efficiency of available adjuvants.Biomaterials,especially functional polymers,are expected to break through these bottlenecks based on the advantages of biocompatibility,degradability,controlled synthesis,easy modification,precise targeting,and immune modulation,which are excellent carriers and adjuvants of vaccines.This review mainly summarizes the application of immunologically effective polymers-enhanced vaccines against viruses-and bacteria-related infectious diseases and predicted their potential improvements.

关 键 词：Immunologically effective biomaterial POLYMER ADJUVANT VACCINE Pathogenic microorganism infection Prevention and treatment 

分 类 号：R392-33[医药卫生—免疫学]