Discussion on Safety of Escitalopram and Paroxetine in the Treatment of Senile Depression to Improve Clinical Efficacy  

作　　者：QUSheng 

机构地区：[1]Qujing Third People's Hospital, Qujing Yun'nan 655000, China

出　　处：《外文科技期刊数据库(文摘版)医药卫生》2022年第7期099-103,共5页

摘　　要：Objective: to compare the safety of escitalopram and paroxetine in the treatment of senile depression. Methods: in this study, 82 patients with senile depression from November 2018 to June 2020 were selected for analysis. They were divided into control group and observation group according to the order of admission, and were treated with paroxetine and escitalopram respectively. The curative effect, adverse reactions, symptom improvement and satisfaction of the two groups were compared. Results: the effective rate was 97.56%(40 cases) in the observation group and 95.12%(39 cases) in the control group, with no significant difference between the two groups (P > 0.05). The incidence of adverse reactions in the observation group was 4.88%(2 cases), which was lower than that in the control group (19.51%, 8 cases). There was significant difference between the two groups (P < 0.05). Before the treatment, the HADM scores and SDS scores of each group were counted, and the depressive symptoms were evaluated. After the scores were calculated, there was no difference between the observation group and the control group, P > 0.05. After the second and fourth weeks of treatment, the HADM scores and SDS scores of each group were counted. After evaluating the depressive symptoms, the scores in the observation group were lower than those in the control group (P < 0.05). At the eighth week of treatment, the HADM scores and SDS scores of each group were counted, and the depressive symptoms were evaluated. After the scores were calculated, there was no difference between the observation group and the control group, P > 0.05. After counting the satisfaction data of each group, it reached 92.68% in the observation group, which was higher than 75.61% in the control group, with significant differences between groups (P < 0.05). Conclusion: the treatment outcome of escitalopram and paroxetine in the treatment of senile depression patients is equivalent, and both can achieve ideal curative effect, but the former has fast effect and less ad

关 键 词：ESCITALOPRAM PAROXETINE senile depression clinical efficacy adverse effect 

分 类 号：R749.4+2[医药卫生—神经病学与精神病学]