PAROXETINE

作品数：32被引量：48H指数：4
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相关领域：医药卫生更多>>
相关作者：郑玉琴邱光苏国辉刘汇文李湄珍更多>>
相关机构：湛江中心人民医院加州大学香港大学成都医学院更多>>
相关期刊：《Chinese Journal of Integrative Medicine》《Acta Pharmacologica Sinica》《Pharmacology & Pharmacy》《World Journal of Anesthesiology》更多>>
相关基金：国家自然科学基金更多>>
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G protein-coupled receptor kinase 2 as a novel therapeutic target for gland fibrosis of Sjögren’s syndrome
《Acta Pharmacologica Sinica》2024年第12期2611-2624,共14页Ru-hong Fang Zheng-wei Zhou Rui Chu Qiu-yun Guan Feng He Ming-li Ge Pai-pai Guo Hua-xun Wu Ling-li Yao Wei Wei Yang Ma Qing-tong Wang 
supported by the National Natural Science Foundation of China(81973314,82373865,81973332);the Anhui Provincial Natural Science Foundation for Distinguished Young Scholars(1808085J28);Collaborative Innovation Project of Key Scientific Research Platform in Anhui Universities(GXXT-2020-066);Anhui Provincial Key R&D Programs(2022e07020042);Program for Upgrading Scientific Research Level of Anhui Medical University(2019xkjT008);Academic Funding for Top-notch Talents in University Disciplines(Majors)of Anhui Province(gxbjzD2021047);Anhui Medical University 2022 Provincial New Era Education Quality Project(2022cxcysjo81);Scientific Research Foundation of Anhui Medical University(2023xkjo77)。
Sjogren’s syndrome(SS)is a chronic,progressive autoimmune disorder characterized by gland fibrosis.We previously found a close correlation between gland fibrosis and the expression of G protein-coupled receptor kinas...
关键词：Sjögren’s syndrome SGECs GRK2 SMAD2/3 gland fibrosis PAROXETINE 
Clinical Observation on Paroxetine in the Treatment of Depression and Anxiety Disorder after Ischemic Stroke
《外文科技期刊数据库(文摘版)医药卫生》2022年第7期068-072,共5页LIUXinhua 
Objective: to explore the clinical efficacy of paroxetine in the treatment of patients with depression and anxiety disorder after ischemic stroke. Methods: 80 patients with depression and anxiety disorder after ischem...
关键词：PAROXETINE ischemic stroke anxiety disorder 
Discussion on Safety of Escitalopram and Paroxetine in the Treatment of Senile Depression to Improve Clinical Efficacy
《外文科技期刊数据库(文摘版)医药卫生》2022年第7期099-103,共5页QUSheng 
Objective: to compare the safety of escitalopram and paroxetine in the treatment of senile depression. Methods: in this study, 82 patients with senile depression from November 2018 to June 2020 were selected for analy...
关键词：ESCITALOPRAM PAROXETINE senile depression clinical efficacy adverse effect 
Paroxetine overdose during pregnancy
《Forensic Sciences Research》2021年第4期237-239,共3页Selin Acar Hilal Erol Elif Keskin Arslan Nusret Uysal BarışKaradaş Tijen Kaya Temiz Yusuf Cem Kaplan 
Paroxetine is a selective serotonin reuptake inhibitor(SSRI)used in the treatment of depression and anxiety disorders.In some epidemiological studies,slightly increased risks of major malformations and cardiac malform...
关键词：Forensic sciences forensic toxicology PAROXETINE OVERDOSE TERATOGENICITY case report 
Paroxetine ameliorates prodromal emotional dysfunction and late-onset memory deficit in Alzheimer’s disease mice被引量：4
《Translational Neurodegeneration》2020年第2期203-213,共11页Peng-Hui Ai Si Chen Xian-Dong Liu Xiao-Na Zhu Yuan-Bo Pan Dong-Fu Feng Shengdi Chen Nan-Jie Xu Suya Sun 
This research was supported by the National Natural Science Foundation of China(81870820 and 31671062 to N.-J.X.,81671047 to S.S.);Grants of Shanghai Brain-Intelligence Project from STCSM(16JC1420500);the Science and Technology Commission of Shanghai Municipality(18JC1420302);Innovation Program of Shanghai Municipal Education Commission(2017-01-07-00-01-E00046).
Background Neuropsychiatric symptoms(NPS)such as depression,anxiety,apathy,and irritability occur in prodromal phases of clinical Alzheimer’s disease(AD),which might be an increased risk for later developing AD.Here ...
关键词：Alzheimer's disease Paroxetine treatment Glutamate receptor Memory deficit 
Electroacupuncture for post-stroke anxiety disorder on the base of the heart-brain theory:A randomized controlled trial被引量：5
《World Journal of Acupuncture-Moxibustion》2020年第1期23-28,共6页Ran LIU San-san CHEN Jun WANG 
Supported by State Administration of Traditional Chinese Medicine,National Traditional Chinese Medicine Clinical Research Base Business Construction Special Research Project:JDZX 2015313.
Objective:To evaluate the differences in the clinical effect and the safety in the treatment of post-stroke anxiety disorder(PSAD)between electroacupuncture(EA)and paroxetine on the base of the heart-brain theory.Meth...
关键词：ELECTROACUPUNCTURE Brain-heart THEORY PAROXETINE POST-STROKE ANXIETY disorder 
基于G-蛋白偶联受体激酶2抑制剂治疗心力衰竭的合理药物设计（英文）被引量：1
《中国药理学与毒理学杂志》2017年第10期945-946,共2页John J TESMER Helen V WALDSCHMIDT Marie C CATO Renee BOULEY Osvaldo CRUZ-RODRIGUEZ Scott D LARSEN 
supported by National Institutes of Health(NIH)grants HL071818,HL086865,and HL122416(to JT);American Heart Association grant 15PRE22730028(to HW);JT and SL were supported by grants from the Center for Discovery of New Medicine,University of Michigan;MCC and OC acknowledge training grant support from the University of Michigan Chemistry Biology Interface training program(NIH grant 5T32GM008597)
G protein-coupled receptors(GPCRs)convert extracellular stimuli in the form of hormones,odorants and light into profound changes in cell homeostasis.Their timely desensitization is critical for cells to rapidly respon...
关键词：herat failure GPCR GPCR kinase PAROXETINE drug design X-ray crystallography 
Administration of Zinc with Paroxetine Improved the Forced Swim Test Behavioral Pattern of Treated Mice in Acute and Sub-Acute Study
《Journal of Behavioral and Brain Science》2015年第7期213-220,共8页Hesham El Refaey Hasan S. Al Amri Abdelkader E. Ashour Atallah F. Ahmed 
Despite progressive improvement in treating major depressive disorder (MDD), it remains mostly unresponsive to one antidepressant medication. Zinc is a brain highly abundant trace metal, a brain derived neurotrophic f...
关键词：DEPRESSION Antidepressants PAROXETINE ZINC 
Comparison of paroxetine and dapoxetine, a novel selective serotonin reuptake inhibitor in the treatment of premature ejaculation被引量：11
《Asian Journal of Andrology》2014年第5期725-727,I0008,I0009,共5页Abdulmuttalip Simsek Sinan Levent Kirecci Onur Kucuktopcu Faruk Ozgor Mehmet Fatih Akbulut Omer Sarilar Unsal Ozkuvanci Zafer Gokhan Gurbuz 
Dapoxetine hydrochloride is a selective serotonin reuptake inhibitor and the first drug approved for the on-demand treatment of premature ejaculation （PE）, Our objective in this study was to characterize the efficac...
关键词：DAPOXETINE PAROXETINE premature ejaculation selective serotonin reuptake inhibitor 
Co-administration of paroxetine and pravastatin causes deregulation of glucose homeostasis in diabetic rats via enhanced paroxetine exposure被引量：5
《Acta Pharmacologica Sinica》2014年第6期792-805,共14页Feng LI Mian ZHANG Dan XU Can LIU Ze-yu ZHONG Ling-ling JIA Meng-yue HU Yang YANG Li LIU Xiao-dong LIU 
Acknowledgements This work was supported by funding from the Graduate Student Research and Innovation Program of Jiangsu Province （No CXZZ12 0325, 2012） and funding for National Natural Science Foundation of China （No 81373482）, National Youth Science Foundation of China （No 81102503）, and the Fundamental Research Funds for the Central Universities （ZD2014YX0026）
Aim： Clinical evidence shows that co-administration of pravastatin and paroxetine deregulates glucose homeostasis in diabetic patients. The aim of this study was to verify this phenomenon in diabetic rats and to eluc...
关键词：diabetes mellitus paroxetine  pravastatin drug-drug interaction PHARMACOKINETICS insulin 5-HT tryptophan hydroxylase 
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