Supported by The Medical Health Science and Technology Project of Zhejiang Provincial Health Commission,No.2024KY138;The Basic Research Project of Wenzhou Municipal Science and Technology Bureau,No.Y20240008;The Key Discipline of Zhejiang Province in Medical Technology(First Class,Category A);The Key Laboratory of School of Laboratory Medicine and Life Sciences,Wenzhou Medical University of China,No.JS2023003.
We comment on an article published by Mansouri et al in the World Journal of Diabetes.L-arginine(L-Arg),a dietary supplement,is a precursor of nitric oxide,can improve cardiovascular disease,and it is important for tr...
BACKGROUND Paracetamol overdose(POD)is the most common cause of acute hepatic failure(AHF)in the United Kingdom.Without urgent orthotopic liver transplant(OLT),mortality is high.Psychiatric assessment for transplant i...
supported by the National Key R&D Program of China(2023YFB3507004);National Natural Science Foundation of China(U21A20148);International Partnership Program of Chinese Academy of Sciences(116134KYSB20210052);Anhui Provincial Natural Science Foundation(2308085QE183,2308085QE181);CASHIPS Director’s Fund(YZJJ2024QN44,YZJJ2023QN43);Heye Health Technology Chong Ming Project(HYCMP2021010);China Post-doctoral Science Foundation(2023M743536);Science Research Fund for Postdoctoral in Anhui Province(2023B669)。
Acetaminophen(APAP),the most frequently used mild analgesic and antipyretic drug worldwide,is implicated in causing 46%of all acute liver failures in the USA and between 40%and 70%in Europe.The predominant pharmacolog...
Background:Clonidine is a centrally acting a2 adrenergic and imidazoline-1 receptor agonist that can cause somnolence,bradycardia,and hypotension within several hours of ingestion.Less well-described but observed by u...
Supported by the National Natural Science Foundation of China(No.81773893,81760812);National Major Scientific and Technological Special Project for"Significant New Drugs Development"(No.2017ZX09301060-001);Jiangxi Province"Thousand Talents Plan"of Scientific and Technological Innovation(No.JXSQ2019201105);Yunnan Province"Ten Thousand Talents"Special Support Plan(No.YNWRQNBJ-2018-190)。
Objecitvie:To compare the liver protective activity of fresh/dried dandelion extracts against acetaminophen(APAP)-induced hepatotoxicity.Methods:Totally 90 Kunming mice were randomly divided into10 groups according to...
BACKGROUND Metformin is arguably the most commonly prescribed oral hypoglycemic agent for the management of diabetes.Due to the lack of randomized control trials,most of the data pertaining to the clinical course,ther...
BACKGROUND:Severe poisoning due to the overdosing of cardiac drugs can lead to cardiovascular failure.In order to decrease the mortality rate,the most severe patients should be transferred as quickly as possible to an...
Rationale:Delayed post-hypoxic leukoencephalopathy(DPHL)is usually an overlooked condition,which arises as a result of a multitude of reversible and irreversible conditions.Patient’s Concern:A 50-year-old female with...
Abuse of drug substances and resultant overdose deaths are no longer very straightforward—viz., attributable to a single chemical entity of known purity. The reality is that most overdose deaths involve polysubstance...
Polysubstance (combinations of substances) abuse and overdose deaths now surpass mono-substance abuse and overdose deaths. Several international and governmental organizations such as the WHO (World Health Organizatio...