Acetaminophen overdose-induced acute liver injury can be alleviated by static magnetic field  

作　　者：Han-Xiao Chen Xin-Yu Wang Biao Yu Chuan-Lin Feng Guo-Feng Cheng Lei Zhang Jun-Jun Wang Ying Wang Ruo-Wen Guo Xin-Miao Ji Wen-Jing Xie Wei-Li Chen Chao Song Xin Zhang 

机构地区：[1]CAS Key Laboratory of High Magnetic Field and Ion Beam Physical Biology,High Magnetic Field Laboratory,Hefei Institutes of Physical Science,Chinese Academy of Sciences,Hefei,Anhui 230031,China [2]Science Island Branch of Graduate School,University of Science and Technology of China,Hefei,Anhui 230026,China [3]Institutes of Physical Science and Information Technology,Anhui University,Hefei,Anhui 230601,China

出　　处：《Zoological Research》2024年第3期478-490,共13页动物学研究（英文）

基　　金：supported by the National Key R&D Program of China(2023YFB3507004);National Natural Science Foundation of China(U21A20148);International Partnership Program of Chinese Academy of Sciences(116134KYSB20210052);Anhui Provincial Natural Science Foundation(2308085QE183,2308085QE181);CASHIPS Director’s Fund(YZJJ2024QN44,YZJJ2023QN43);Heye Health Technology Chong Ming Project(HYCMP2021010);China Post-doctoral Science Foundation(2023M743536);Science Research Fund for Postdoctoral in Anhui Province(2023B669)。

摘　　要：Acetaminophen(APAP),the most frequently used mild analgesic and antipyretic drug worldwide,is implicated in causing 46%of all acute liver failures in the USA and between 40%and 70%in Europe.The predominant pharmacological intervention approved for mitigating such overdose is the antioxidant N-acetylcysteine(NAC);however,its efficacy is limited in cases of advanced liver injury or when administered at a late stage.In the current study,we discovered that treatment with a moderate intensity static magnetic field(SMF)notably reduced the mortality rate in mice subjected to high-dose APAP from 40%to 0%,proving effective at both the initial liver injury stage and the subsequent recovery stage.During the early phase of liver injury,SMF markedly reduced APAPinduced oxidative stress,free radicals,and liver damage,resulting in a reduction in multiple oxidative stress markers and an increase in the antioxidant glutathione(GSH).During the later stage of liver recovery,application of vertically downward SMF increased DNA synthesis and hepatocyte proliferation.Moreover,the combination of NAC and SMF significantly mitigated liver damage induced by high-dose APAP and increased liver recovery,even 24 h post overdose,when the effectiveness of NAC alone substantially declines.Overall,this study provides a noninvasive non-pharmaceutical tool that offers dual benefits in the injury and repair stages following APAP overdose.Of note,this tool can work as an alternative to or in combination with NAC to prevent or minimize liver damage induced by APAP,and potentially other toxic overdoses.

关 键 词：ACETAMINOPHEN Acute liver injury Static magnetic fields Oxidative stress DNA synthesis 

分 类 号：R575[医药卫生—消化系统]