COCAINE

作品数：60被引量：75H指数：5
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相关机构：中国科学院上海应用物理研究所密苏里大学华中科技大学复旦大学上海医学院更多>>
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光干预降低可卡因记忆消退后复吸行为的神经环路机制
《Science Bulletin》2023年第18期2063-2076,M0004,共15页富昀炜 杨妍 黄鲁 黄晓丹 杨倩 陶倩 吴冀津 苏国辉 林嵩 袁逖飞 任超然 
supported by the STI2030-Major Projects(2021ZD0203100);the National Natural Science Foundation of China(31922030,32171010,31771170,31900720,and 32171009);the Guangdong Basic and Applied Basic Research Foundation(2023B1515040010,2021B1515020035,2019A1515011598,and 2023A1515010478);the Science and Technology Program of Guangdong(2018B030334001);the Science and Technology Program of Guangzhou(202007030012);the Programme of Introducing Talents of Discipline to Universities(B14036).
毒品成瘾已经成为一个严峻挑战,特别是因滥用造成的可卡因高复吸率给社会带来严重负担。尽管我们在神经生物学层面对成瘾的理解取得了显著进展,但仍缺乏有效降低复吸的戒断手段.在这项研究中,我们发现在可卡因戒断期实施亮光干预(BLT)...
关键词：Light treatment Lateral habenula Cocaine memory Visual circuit 
A Curious Case of Methaemoglobinemia
《Health》2023年第2期93-98,共6页Farris Latief Joseph Ngwira Ali Saiepour Amirah Latief 
The most frequent cause of raised methaemoglobin is from recreational drug use, with oxidation of the haem molecule leading to methaemoglobinaemia. Our case describes that of a man in his early thirties who presented ...
关键词：METHAEMOGLOBINAEMIA HYPOXIA COCAINE Drug Induced 
A Sandwich-type Lateral Flow Strip Using a Split, Single Aptamer for Point-of-Care Detection of Cocaine被引量：2
《Journal of Analysis and Testing》2022年第2期120-128,共9页Le Jing Chong-Yu Xie Qian-Qian Li Hui-Fang Yao Mei-Qing Yang Hui Li Fan Xia Shao-Guang Li 
supported by the National Natural Science Foundation of China(22090050,22122410,21874121);the National Key Research and Development Program of China(2018YFE0206900);Hubei Provincial Natural Science Foundation of China(2020CFA037);Zhejiang Provincial Natural Science Foundation of China(LD21B050001)
The sandwich-type lateral fl ow assays relying on dual aptamers with high sensitivity and specifi city have been broadly explored.However,it is unlikely to match a pair of specifi c aptamers that can bind a small mole...
关键词：Lateral flow strip Split aptamer SANDWICH-TYPE AuNPs COCAINE 
Polysubstance Use and Overdose Visualized via Maps: Amphetamines and Cocaine
《Pharmacology & Pharmacy》2022年第5期140-148,共9页Robert B. Raffa Joseph V. Pergolizzi Jr. Herm Cukier 
Abuse of drug substances and resultant overdose deaths are no longer very straightforward—viz., attributable to a single chemical entity of known purity. The reality is that most overdose deaths involve polysubstance...
关键词：Polysubstance Use/Abuse Use Disorder OVERDOSE MAPS AMPHETAMINE COCAINE 
Levamisole-Adultered Cocaine: Vasoconstrictive and Vasculitis Effects Occurring Simultaneously
《Case Reports in Clinical Medicine》2022年第5期167-174,共8页María A. Rodríguez-Santiago Hillarie Ríos-Torres Giulianni Oliveras-Maldonado Valeria Martinez-Lebrón Suheiry Márquez-Márquez Adianez Santiago-Santiago Salvador Vilá-Pérez Marcel Mesa-Pabón 
This case presents a rarely seen combination of two Cocaine-induced syndromes occurring simultaneously. Levamisole-adultered cocaine leads to Levamisole-induced Vasculitis (LIV), while cocaine’s vasoconstrictive effe...
关键词：Levamisole-Induced Vasculitis Cocaine-Induced Midline Destructive Lesions Cocaine’s Side Effect Spectrum 
Repeated cocaine administration upregulates CB_(2) receptor expression in striatal medium-spiny neurons that express dopamine D_(1) receptors in mice
《Acta Pharmacologica Sinica》2022年第4期876-888,共13页Hai-Ying Zhang Lindsay De Biase Ramesh Chandra Hui Shen Qing-Rong Liu Eliot Gardner Mary Kay Lobo Zheng-Xiong Xi 
This research was supported by the Intramural Research Program(IRP)of the National Institute on Drug Abuse(NIDA)(DA000633-01);National Institutes of Health(NIH);grant support for MKL in UMB(NIH grant R01DA038613).
Cannabinoid CB2 receptors(CB2R)are importantly involved in drug reward and addiction.However,the cellular mechanisms underlying CB2R action remain unclear.We have previously reported that cocaine self-administration u...
关键词：COCAINE CANNABINOID CB_(2)receptor MICROGLIA SELF-ADMINISTRATION D_(1)-MSNs 
mTOR regulates cocaine-induced behavioural sensitization through the SynDIG1–GluA2 interaction in the nucleus accumbens被引量：2
《Acta Pharmacologica Sinica》2022年第2期295-306,共12页Hong-chun Li Jia-mei Zhang Rui Xu Yong-hai Wang Wei Xu Rong Chen Xue-mei Wan Hao-luo Zhang Liang Wang Xiao-jie Wang Lin-hong Jiang Bin Liu Ying Zhao Yuan-yuan Chen Yan-ping Dai Min Li Hua-qin Zhang Zhen Yang Lin Bai Jie Zhang Hong-bo Wang Jing-wei Tian Ying-lan Zhao Xiao-bo Cen 
This work was partially supported by National Natural Science Foundation of China(Grants 82071494,81871043,81272459);the National Science and Technology Major Project(2018ZX09201017-009,2018ZX09201018-011);“1·3·5 Project for Disciplines of Excellence,West China Hospital,Sichuan University”.
Behavioral sensitization is a progressive increase in locomotor or stereotypic behaviours in response to drugs. It is believed to contribute to the reinforcing properties of drugs and to play an important role in rela...
关键词：TOR behavioural sensitization SynDIG1 GluA2 nucleus accumbens 
Simvastatin Blocks Reinstatement of Cocaine-induced Conditioned Place Preference in Male Mice with Brain Lipidome Remodeling
《Neuroscience Bulletin》2021年第12期1683-1702,共20页Wei Xu Yuman He Jiamei Zhang Hongchun Li Xuemei Wan Menglu Li Yonghai Wang Rui Xu Haoluo Zhang Yanping Dai Haxiaoyu Liu Linhong Jiang Ying Zhao Xiaobo Cen 
the National Natural Science Foundation of China(81871043 and 82071494);the National Science and Technology Major Project of China(2018ZX09201017 and 2018ZX09201018);the 1.3.5 Project for Disciplines of Excellence,West China Hospital,Sichuan University(ZYGD18024).
Drug-associated reward memories are conducive to intense craving and often trigger relapse.Simvastatin has been shown to regulate lipids that are involved in memory formation but its influence on other cognitive proce...
关键词：SIMVASTATIN Cocaine relapse Extinction LIPIDOME Conditioned place preference 
Aberrant expression of BDNF might serve as a candidate target for cocaine- induced psychosis: insights from bioinformatics analysis and microarray validation被引量：3
《General Psychiatry》2021年第5期45-52,共8页Youwei Zhu Yan Zhao Xiaomin Xu Hang Su Xiaotong Li Na Zhong Haifeng Jiang Jiang Du Min Zhao 
This work was supported by the National Nature Science Foundation(81771436);Program of Shanghai Academic Research Leader(17XD1403300);Shanghai Municipal Health and Family Planning Commission(2017ZZ02021,2018YQ45 and 20184Y0134);Shanghai Key Laboratory of Psychotic Disorders(13DZ2260500);Shanghai Municipal Science and Technology Major Project(2018SHZDZX05);Shanghai Sailing Program(19YF1442100);Shanghai Mental Health Center Program(2018-QH 02,2020-YJ 06,CRC2018YB02).
Background Cocaine use disorder(CUD)and associated psychosis are major public health issues worldwide,along with high relapse outcome and limited treatment options.Exploring the molecular mechanisms underlying cocaine...
关键词：alterations analysis INSIGHT 
Substances of abuse consumption among patients seeking medical help for uro-andrological purposes:a sociobehavioral survey in the real-life scenario被引量：1
《Asian Journal of Andrology》2021年第5期456-461,共6页Federico Belladelli Luca Boeri Paolo Capogrosso Walter Cazzaniga Eugenio Ventimiglia Luigi Candela Edoardo Pozzi Andrea Baudo Massimo Alfano Costantino Abbate Francesco Montorsi Andrea Salonia 
Substances of abuse(SoA),as well as smoking and alcohol consumption,are well known for their impact on male fertility status,erectile function,and ejaculation.We assessed SoA consumption habits in a cohort of men seek...
关键词：CANNABIS COCAINE erectile dysfunction male infertility risk factors substances of abuse 
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