SELF-ADMINISTRATION

作品数：16被引量：30H指数：3
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Blockade of the Dopamine D3 Receptor Attenuates Opioids-Induced Addictive Behaviours Associated with Inhibiting the Mesolimbic Dopamine System被引量：2
《Neuroscience Bulletin》2023年第11期1655-1668,共14页Rong-Rong Hu Meng-Die Yang Xiao-Yan Ding Ning Wu Jin Li Rui Song 
Opioid use disorder(OUD)has become a considerable global public health challenge;however,potential medications for the management of OUD that are effective,safe,and nonaddictive are not available.Accumulating preclini...
关键词：Opioid use disorder D3 receptors DOPAMINE SELF-ADMINISTRATION Conditioned place preference 
Actively separated microneedle patch for sustained-release of growth hormone to treat growth hormone deficiency被引量：2
《Acta Pharmaceutica Sinica B》2023年第1期344-358,共15页Li Yang Qingyun Liu Xinhui Wang Nansha Gao Xiuzhen Li Hongzhong Chen Lin Mei Xiaowei Zeng 
financial support from the National Natural Science Foundation of China(32071342 and 31922042);Guangdong Special Support Program(2019TQ05Y209);the Natural Science Foundation of Guangdong Province(2021A1515010431);the Fundamental Research Funds for the Central Universities(Nos.2021-RC310-005,2020-RC320-002 and 2019PT320028);Chinese Academy of Medical Sciences Innovation Fund for Medical Sciences(2021-I2M-1-058)。
Growth hormone deficiency(GHD)has become a serious healthcare burden,and presents a huge impact on the physical and mental health of patients.Here,we developed an actively separated microneedle patch(PAA/NaHCO_(3)^(-)...
关键词：MICRONEEDLE Silk protein SELF-ADMINISTRATION SUSTAINED-RELEASE Actively separated Growth hormone deficiency Growth hormone Long-acting GH 
Repeated cocaine administration upregulates CB_(2) receptor expression in striatal medium-spiny neurons that express dopamine D_(1) receptors in mice被引量：1
《Acta Pharmacologica Sinica》2022年第4期876-888,共13页Hai-Ying Zhang Lindsay De Biase Ramesh Chandra Hui Shen Qing-Rong Liu Eliot Gardner Mary Kay Lobo Zheng-Xiong Xi 
This research was supported by the Intramural Research Program(IRP)of the National Institute on Drug Abuse(NIDA)(DA000633-01);National Institutes of Health(NIH);grant support for MKL in UMB(NIH grant R01DA038613).
Cannabinoid CB2 receptors(CB2R)are importantly involved in drug reward and addiction.However,the cellular mechanisms underlying CB2R action remain unclear.We have previously reported that cocaine self-administration u...
关键词：COCAINE CANNABINOID CB_(2)receptor MICROGLIA SELF-ADMINISTRATION D_(1)-MSNs 
Identification of adrafinil and its main metabolite modafinil in human hair.Self-administration study and interpretation of an authentic case被引量：1
《Forensic Sciences Research》2020年第4期322-326,共5页Alice Ameline Laurie Gheddar Jean-Sébastien Raul Pascal Kintz 
For several years,the misuse of stimulant substances is increasingly observed both in the field of sport,to improve the functions of the body and therefore to be more performant,and also by non-athletes to make life m...
关键词：Forensic sciences forensic toxicology adrafinil MODAFINIL human hair UPLC-MS/MS STIMULANTS 
Cannabidiol does not display drug abuse potential in mice behavior被引量：2
《Acta Pharmacologica Sinica》2019年第3期358-364,共7页Adrián Viudez-Martínez María S.García-Gutiérrez Juan Medrano-Relinque Carmen M.Navarrón Francisco Navarrete Jorge Manzanares 
Recent evidence suggests that cannabidiol(CBD)may be useful for the treatment of different neuropsychiatric disorders.However,some controversy regarding its profile as a drug of abuse hampers the further development o...
关键词：CANNABIDIOL CANNABINOID receptor drug ABUSE conditioned place PREFERENCE oral CBD SELF-ADMINISTRATION WITHDRAWAL syndrome 
Cannabinoid CB1 receptor neutral antagonist AM4113 inhibits heroin self-administration without depressive side effects in rats被引量：2
《Acta Pharmacologica Sinica》2019年第3期365-373,共9页Xiang-hu He Chloe J.Jordan Kiran Vemuri Guo-hua Bi Jia Zhan Eliot L.Gardner Alexandros Makriyannis Yan-lin Wang Zheng-xiong Xi 
Cannabinoid CB1 receptors(CB1Rs)have been shown to be a promising target in medication development for the treatment of addiction.However,clinical trials with SR141716A(rimonabant,a selective CB1R antagonist/inverse a...
关键词：CB1 receptors AM4113 SR141716A CB1 neutral antagonist CB1 inverse agonist drug REWARD AVERSION depression SELF-ADMINISTRATION brain-stimulation REWARD 
Intravenous morphine self-administration alters accumbal microRNA profiles in the mouse brain被引量：1
《Neural Regeneration Research》2018年第1期77-85,共9页Juhwan Kim Heh-In Im Changjong Moon 
funded by the National Research Council of Science & Technology(NST)grant by the Korean government(MSIP)(No.CRC-15-04-KIST);the National Research Foundation of Korea under the grant(No.NRF-2017R1A2B200399;Mid-career Researcher Program)
A significant amount of evidence indicates that microRNAs （miRNAs） play an important role in drug addiction. The nucleus accumbens （NAc） is a critical part of the brain’s reward circuit and is involved in a varie...
关键词：nerve regeneration nucleus accumbens MICRORNA MORPHINE SELF-ADMINISTRATION BIOINFORMATICS neural regeneration 
Abuse-related effects of synthetic cathinones：importance of DAT/SERT relationships
《中国药理学与毒理学杂志》2017年第10期951-951,共1页Brenda M GANNON Michael H BAUMANN Kenner C RICE Gregory T COLLINS 
supported by NIH and NIDA(R01DA039146;T32DA031115);NIH Intramural Research Programs
OBJECTIVE Wide spread abuse of synthetic cathinones found in bath salts preparations has resulted in regulation of some cathinones internationally.Chemists skirt these laws by altering the chemical structures of first...
关键词：synthetic cathinones bath salts SELF-ADMINISTRATION dopamine transporter serotonin transporter 
N-acetylaspartylglutamate Inhibits Heroin Self-Administration and Heroin-Seeking Behaviors Induced by Cue or Priming in Rats被引量：1
《Neuroscience Bulletin》2017年第4期396-404,共9页Huaqiang Zhu Miaojun Lai Weisheng Chen Disen Mei Fuqiang Zhang Huifeng Liu Wenhua Zhou 
supported by the National Basic Research Program of China(2015CB553504);the National Natural Science Foundation of China(81471350 and 81671321);the Natural Science Foundation of Ningbo Municipality,Zhejiang Province,China(2015A610193)
Activation of presynaptic group II metabotropic glutamate receptors（mGluR2/3） inhibits drug reward and drug-seeking behavior, but the role of N-acetylaspartylglutamate（NAAG）, an agonist of endogenous mGluR2/3,in h...
关键词：Glutamate OPIOID Metabotropic glutamate receptor Reward ADDICTION 
A Study on the Innovations of Rural Planning and Management of Chengdu, Sichuan, China
《China City Planning Review》2016年第3期58-65,共8页Zeng Fan Qiu Jian 
sponsored by the Science and Technology Support Project Funding of Sichuan Province (No. 2013FZ0009);the National Natural Science Foundation of China (No. 51278421; No.51678487)
China has adopted a dual urban-rural administration system for many years which gives far more attention to cities than to rural areas. Designated as a National Comprehensive Reform Experiment Area for Coordinated Urb...
关键词：bottom-up self-administration Chengdu practice post-disaster reconstruction rural planning rural planning management 
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