the National Natural Science Foundation of China(No.21971266);the Guangdong Provincial Key Platforms and Major Scientific Research Projects of Universities(No.2019KQNCX101);the Pan Deng Project of Guangdong Province(No.pdjh2020b0431);We also thank Dr.Long Jiang from Sun Yat-sen University instrumental analysis and research center.
Chiral-at-metal strategy was developed to resolve the essential sulfoxide pharmaceutical intermediates R-modafinil acid and its ana-logues with high yields and ee values.The efficient resolution process was achieved b...
For several years,the misuse of stimulant substances is increasingly observed both in the field of sport,to improve the functions of the body and therefore to be more performant,and also by non-athletes to make life m...
This review seeks to describe the use and effects of the drug modafinil. Specifically, it presents the research of the impact of modafinil for people with diagnosis and experience of schizophrenia. Recent reviews have...
Modafinil is employed for the treatment of narcolepsy and other sleep disorders like idiopathic hypersornnia. Modafinil is involved in the modulation of orexin, a hypothalamic neuropeptide that regulates wakefulness. ...
Aim: To describe the population pharmacokinetic profile of modafinil acid and to compare the extent of metabolism of modafinil into modafinil acid in 5 major ethnic groups (Han, Mongolian, Korean, Uygur, and Hui) o...
Pharmacological treatment of narcolepsy is complex. We reported a case of recurrent episodes of polymorphic ventricular tachycardia attributed to the use of modafinil, a recently approved wake-promoting agent for narc...
Entire Armed Forces 15 Medicine Health Science and Technology Attack Topic(Grant No.06G023)
The purpose of this study was to determine the pharmacokinetic characteristics of modafinil and its metabolite modafinil acid in healthy subjects including Chinese Mongolian, Korean and Uyghur, and assess the influenc...