BACKGROUND More studies explored the prevalence,causes,associated conditions,and therapeutic strategies of narcolepsy.With an increasing focus on understanding narcolepsy’s prevalence,associated conditions,and therap...
Background: Narcolepsy type 1 is a sleep disorder characterized by excessive sleepiness along with cataplexy and/or hypocretin deficiency. We present a case of narcolepsy type 1 in which the cataplexy symptoms were re...
supported by a grant from the Peking University Clinical Scientist Program(No.BMU2019LCKXJ001).
A 16-year-old male adolescent was hospitalized complaining of intermittent dizziness,drowsiness,and fatigue for approximately 2 years.The patient had an episode of fever and pharyngalgia lasting nearly 2 weeks and had...
supported by the Research Project of Central Health Care Special Fund,China,No.W2017BJ52(to JZ)
Early-and late-onset narcolepsy constitutes two distinct diagnostic subgroups.However,it is not clear whether symptomology and genetic risk factors differ between early-and late-onset narcoleptics.This study compared ...
supported by the Sigrid Jusélius Foundation,the Academy of Finland(292393);Helsinki University Central Hospital(TYH2018313,TYH2019311)grants.
Gangliosides are structurally and functionally polymorphic sialic acid containing glycosphingolipids that are widely distributed in the human body.They play important roles in protecting us against immune attacks,yet ...
Atopic dermatitis(AD)and narcolepsy type 1(NT1)are two distinct diseases that have not been classically shown to be related.The potential connection between the known immunological aetiology of AD and the proposed aut...
Background:Recent genome-wide association studies have identified an important role of T-cell receptor α(TRA) gene in the development of narcolepsy type 1.However,the role of TRA haplotype polymorphisms in the sympto...
supported by the National Natural Science Foundation of China (81700088 and 81671765);the Key International (Regional) Cooperation Program of the National Natural Science Foundation of China (81420108002);the National Basic Research Development Program (973 Program) of China (2015CB856405);the Beijing Municipal Natural Science Foundation (7172121)
The present study was aimed to evaluate restingstate functional connectivity and topological properties of brain networks in narcolepsy patients compared with healthy controls.Resting-state fMRI was performed in 26 ad...
Objective To discusses the predictive value of typical cataplexy + HLA-DQB1 * 0602 positive to hypocretin-1(HCRT-1)reduction in cerebrospinal fluid(CSF)in patients with narcolepsy.Methods A total of 165 narcoleptic pa...
Since the early 1800s vaccines have saved numerous lives by preventing lethal infections.However,during the past two decades,there has been growing awareness of possible adverse events associated with vaccinations,cul...