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SUBTYPE: 作品数：251被引量：565H指数：11; 导出分析报告; 相关领域：医药卫生更多>>; 相关作者：张烨董婕董丽波舒跃龙王大燕更多>>; 相关机构：中国药科大学天津医科大学南京医科大学中国疾病预防控制中心更多>>; 相关期刊：更多>>; 相关基金：国家自然科学基金国家重点基础研究发展计划广东省自然科学基金中国博士后科学基金更多>>

Prognostic significance and multidimensional roles of interferon regulatory factors in cancer biology:A comprehensive analysis: 《Genes & Diseases》2025年第3期15-18,共4页Guo Ji Shuyuan Xian Jiaqi Song Shiyu Mao Man Pi Qiongyi Huang Xue Han Jian Yin Zan Wu Runzhi Huang Dongyan Han Zhengyan Chang; supported in part by the National Natural Science Foundation of China(No.82002923,82203505).; Interferon regulatory factors(IRFs)are transcription factors with a conserved N-terminal helix-loop-helix DNA-binding domain 1.IRF family plays a pivotal role in regulating interferon transcription,immune cell develop...; 关键词：interferon regulatory factors irfs interferon regulatory factors multidimensional correlation analysiswe multidimensional roles STEMNESS transcription factors immune subtype cancer biology

Comprehensive understanding of a rare disease:Cardiac metastatic tumor,a double-center 10-year case review: 《World Journal of Cardiology》2025年第2期43-51,共9页Ling-Yun Luo Tian-Shu Yang Zhen He Li Lin Xue-Lian Luo; BACKGROUND Cardiac metastatic tumors(CMTs)are rare yet pose significant medical concerns.Clinical studies on CMT are limited,particularly those involving multicenter data analysis.AIM To systematically analyze the eti...; 关键词：Cardiac metastatic tumor SUBTYPE PROGNOSIS COAGULATION Primary tumor

Integrated analysisof monocyte infiltration and differential gene expressionin hypertrophic obstructive cardiomyopathy: 《South China Journal of Cardiology》2024年第4期260-274,共15页QIN Xian-yu TAN Jian ZHENG Hao-sheng ZHENG Yu-zhen LIAO Hong-ying ZHUANG Jian; National Natural Science Foundation of China(No.82102955);Guangzhou Basic Research Project(No.02201011326)。; Background Hypertrophic obstructive cardiomyopathy(HOCM)is one of the main reasons for sudden cardiac death(SCD)in young people.Researches has revealed that immune-related genes are closely relevant to HOCMprogression...; 关键词：Hypertrophic cardiomyopathy Hypertrophic obstructive cardiomyopathy Immune infiltration Immune cell subtype

Microglia subtypes in Alzheimer’s disease: insights from single-cell omics: 《Journal of Translational Neuroscience》2024年第4期14-22,共9页Ruikang Han Feng Li; Microglia are immune-competent cells involved in maintaining brain homeostasis through their capacity to prune synapses and continuously survey the brain environment.The activation of microglia is one of the most prom...; 关键词：MICROGLIA Alzheimer’s disease im-munity SUBTYPE heterogeneity NEUROINFLAMMATION lipid metabolism

Subtype‑specific neurons from patient iPSCs display distinct neuropathological features of Alzheimer’s disease: 《Cell Regeneration》2024年第1期150-166,共17页Ran Tao Chunmei Yue Zhijie Guo Wenke Guo Yao Yao Xianfa Yang Zhen Shao Chao Gao Jianqing Ding Lu Shen Shengdi Chen Naihe Jing; National Key Basic Research and Development Program of China(2019YFA0801402,2018YFA0800100,2018YFA0107200,2018YFA0801402);Major Project of Guangzhou National Laboratory(GZNL2023A02005);Strategic Priority Research Program of the Chinese Academy of Sciences(XDA16020501,XDA16020404);National Natural Science Foundation of China(31800854,32130030,31900454)。; Alzheimer’s disease(AD)is a progressive neurodegenerative disorder characterized by massive neuronal loss in the brain.Both cortical glutamatergic neurons and basal forebrain cholinergic neurons(BFCNs)in the AD brain...; 关键词：Alzheimer’s disease(AD) IPSC Cellular model Basal forebrain cholinergic neuron(BFCN) CORTICAL

Genetic and biological properties of H10Nx influenza viruses in China: 《Journal of Integrative Agriculture》2024年第11期3860-3869,共10页Yina Xu Hailing Li Haoyu Leng Chaofan Su Siqi Tang Yongtao Wang Shiwei Zhang Yali Feng Yanan Wu Daxin Wang Ying Zhang; supported by the National Key Research and Development Program of China(2021YFD1800200);the National Natural Science Foundation of China(32170539,32000357);Liaoning Revitalization Talents Program,China(XLYC2007114)。; H10 subtype avian influenza viruses(AIV)have been circulating in China for 40 years.H10 AIVs in China have expanded their host range from wild birds to domestic poultry and mammals,even human.Most of the H10 subtype A...; 关键词：avian influenza virus H10 subtype ADAPTATION PATHOGENICITY

A lactate‐responsive gene signature predicts the prognosis and immunotherapeutic response of patients with triple‐negative breast cancer: 《Cancer Innovation》2024年第4期26-42,共17页Kaixiang Feng Youcheng Shao Jun Li Xiaoqing Guan Qin Liu Meishun Hu Mengfei Chu Hui Li Fangfang Chen Zongbi Yi Jingwei Zhang; National Natural Science Foundation of China,Grant/Award Number:82303823;Fundamental Research Funds for the Central Universities,Grant/Award Number:42023kf0226。; Background:Increased glycolytic activity and lactate production are characteristic features of triple‐negative breast cancer(TNBC).The aim of this study was to determine whether a subset of lactate‐responsive genes(...; 关键词：IMMUNOTHERAPY LACTATE risk model SUBTYPE TNBC

Acute suppurative terminal cholangitis:Clinical characteristics of a new subtype of acute cholangitis被引量：2: 《Hepatobiliary & Pancreatic Diseases International》2024年第3期293-299,共7页Rong-Tao Zhu Ye Li Chi-Xian Zhang Wei-Jie Wang Ruo-Peng Liang Jian Li Kai Bai Yu-Ling Sun; This study was supported by a grant from the National Natural Science Foundation of China(81870457).; Background:Acute suppurative terminal cholangitis(ASTC)is rarer than acute obstructive cholangitis and is not well studied.To explore this subtype of acute cholangitis,we described our clinical experience with ASTC.Me...; 关键词：Acute suppurative terminal cholangitis Acute cholangitis Gram-negative bacterial infections DIAGNOSIS Treatment

A novel homozygous missense variant in ARSK causes MPS X,a new subtype of mucopolysaccharidosis: 《Genes & Diseases》2024年第3期87-90,共4页Miao Sun Cornelia K.Kaminsky Philip Deppe Mai-Brittllse Frederic M.Vaz Barbara Plecko Torben Lubke Linda M.Randolph; Mucopolysaccharidoses(MPS)are a group of rare inborn errors of metabolism caused by defective lysosomal enzymes which prevent cells from degrading and recycling certain carbohydrates and fats,resulting in the storage ...; 关键词：metabolism doses polys

CBioProfiler:A Web and Standalone Pipeline for Cancer Biomarker and Subtype Characterization: 《Genomics, Proteomics & Bioinformatics》2024年第3期153-165,共13页Xiaoping Liu Zisong Wang Hongjie Shi Sheng Li Xinghuan Wang; Cancer is a leading cause of death worldwide,and the identification of biomarkers and subtypes that can predict the long-term survival of cancer patients is essential for their risk stratification,treatment,and progno...; 关键词：CBioProfiler Cancer biomarker Cancer subtype Machine learning Web app

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