Microglia subtypes in Alzheimer’s disease: insights from single-cell omics  

作　　者：Ruikang Han Feng Li 

机构地区：[1]School of Basic Medical Sciences,Capital Medical University,Beijing 100069,China [2]School of Stomatology,Capital Medical University,Beijing 100050,China [3]Department of Neurobiology,Capital Medical University,Beijing 100069,China

出　　处：《Journal of Translational Neuroscience》2024年第4期14-22,共9页转化神经科学电子杂志（英文）

摘　　要：Microglia are immune-competent cells involved in maintaining brain homeostasis through their capacity to prune synapses and continuously survey the brain environment.The activation of microglia is one of the most prominent characteristics of Alzheimer’s disease(AD),a severe neurodegenerative disease featuring extra-cellular deposits of amyloid-βplaques(Aβplaques)and intracellular neurofibrillary tangles(NFTs)as the result of tau hyperphosphorylation.Whether microglia activation is beneficial or detrimental for brains with AD is still con-troversial.In this article,we review recent studies focus-ing on microglia phenotypes in AD by single-cell omics,to understand the signature genes,functions,and regula-tory factors of each phenotype.A profound understanding of the heterogeneity of microglial phenotypes will sug-gest new avenues for treatments for AD.

关 键 词：MICROGLIA Alzheimer’s disease im-munity SUBTYPE heterogeneity NEUROINFLAMMATION lipid metabolism 

分 类 号：R749.16[医药卫生—神经病学与精神病学]