The brain circuits underlying sleep-wake regulation are not fully understood,although significant progress has been made in the past few decades[1-3].Different sleep-wake states arecontrolledbydistinct neural circuits.
Background: Narcolepsy type 1 is a sleep disorder characterized by excessive sleepiness along with cataplexy and/or hypocretin deficiency. We present a case of narcolepsy type 1 in which the cataplexy symptoms were re...
Objective To discusses the predictive value of typical cataplexy + HLA-DQB1 * 0602 positive to hypocretin-1(HCRT-1)reduction in cerebrospinal fluid(CSF)in patients with narcolepsy.Methods A total of 165 narcoleptic pa...
supported by the National Natural Science Foundation of China (30700201, 31070959, 31071021, 31171050);the National Natural Science Foundation of China/Research Grants Council of Hong Kong Joint Research Scheme (30931160433);the Research Fund for the Doctoral Program of Higher Education, Ministry of Education, China (20070284057 and 20100091110016);Program for New Century Excellent Talents in University, Fundamental Research Funds for the Central Universities, Ministry of Education, China (1094020806 and 1095020821);the Natural Science Foundation of Jiangsu Province, China (BK2011014)
The neuropeptide orexin is synthesized by neurons exclusively located in the hypothalamus. However, these neurons send axons over virtually the entire brain and spinal cord and therefore constitute a unique central or...