supported by grants from the National Natural Science Foundation of China(No.82174496,No.82374574);Shanghai Key Discipline of Traditional Chinese Medicine Construction Project(No.shzyyzdxk–2024113)。
Objective:This study investigates the sleep-modulating effects of ginsenoside Rg1(Rg1,C_(42)H_(72)O_(14)),a key bioactive component of ginseng,and elucidates its underlying mechanisms.Methods:C57BL/6J mice were intrap...
supported by grants from the China Science and the Technology Innovation 2030 for Brain Science and Brain-Inspired Technology[grant numbers 2021ZD0203404 and 2022ZD0205600];the National Natural Science Foundation of China[grant numbers 31871210 and 82171481];the Innovation and Development Joint Fund of Chongqing National Natural Science Foundation[grant number CSTB2023NSCQ-LZX0141].
Proper timing of vigilance states serves fundamental brain functions.Although disturbance of sleep onset rapid eye movement(SOREM)sleep is frequently reported after orexin deficiency,their causal relationship still re...
supported by the National Key Research and Development Program of China,Nos.2016YFC1306300(to XMW),2016YFC1306000;the National Key R&D Program of China-European Commission Horizon 2020,No.2017YFE0118800-779238(to YXW);the Notional Natural Science Foundation of Chino,Nos.81970992(to WZ),81571229(to WZ),81071015(to WZ),30770745(to WZ);Capital's Funds for Health Improvement and Research(CFH),No.2022-2-2048(to WZ);the Key Technology R&D Program of Beijing Municipal Education Commission,No.kz201610025030(to WZ);the Natural Science Foundation of Beijing,No.7082032(to WZ);the Key Project of the Natural Science Foundation of Beijing,No.4161004(to WZ);Capitol Clinical Characteristic Applicotion Research,No.Z121107001012161(to WZ);Project of Scientific and Technological Development of Traditional Chinese Medicine in Beijing,No.JJ2018-48(to WZ);High Level Technical Personnel Training Project of Beijing Health System of China,No.2009-3-26(to WZ);Excellent Personnel Training Project of Beijing,No.20071D0300400076(to WZ);Important National Science&Technology Specific Project,No.2011ZX09102-003-01(to WZ);Beijing Healthcare Research Project,No.JING-15-2(to WZ);Basic-Clinicol Research Cooperation Funding of Capitol Medical University of China,Nos.2015-JL-PT-X04(to WZ),10JL49(to WZ),14JL15(to WZ);the Natural Science Foundation of Capital Medical University;Beijing;China,No.PYZ2018077(to PG);Youth Research Fund of Beijing Tianton Hospital of Capital Medical University of China,Nos.2015-YQN-14(to PG),2015-YQN-15,2015-YQN-17。
Previous studies have shown that reduced sleep duration,sleep fragmentation,and decreased sleep quality in patients with Alzheimer's disease are related to dysfunction in orexin signaling.At the same time,blood-brain ...