Predictive value of typical cataplexy+DQB1~* 0602 positive to hypocretin-1 reduction in cerebrospinal fluid in patients with narcolepsy  

作　　者：CHANG Yuan 常远(Dept Respir Med,Peking Univ Intl Hosp)

机构地区：[1]Dept Respir Med,Peking Univ Intl Hosp

出　　处：《China Medical Abstracts(Internal Medicine)》2018年第4期221-221,共1页中国医学文摘（内科学分册（英文版）

摘　　要：Objective To discusses the predictive value of typical cataplexy + HLA-DQB1 * 0602 positive to hypocretin-1(HCRT-1)reduction in cerebrospinal fluid(CSF)in patients with narcolepsy.Methods A total of 165 narcoleptic patients,who were diagnosed at the Sleep Center of Peking University People's Hospital and Peking University International Hospital from March 2003 to March 2017,were recruited.The CSF HCRT-1 level and DQB1* 0602 were measured in all the subjects.The narcoleptic patients were divided into two groups:typical cataplexy + DQB1 * 0602 positive CH group,and untypical cataplexy and DQB1 * 0602 negative simultaneously NCH group.The HCRT-1 level in CSF was declared to have a serious reduction when HCRT-1≤110 ng/L.According to this standard,the CH group and the NCH group were subdivided into sub-groups and the data was analyzed to investigate the predictive value of typical cataplexy + HLA-DQB1 * 0602 positive to HCRT-1 reduction.Results There were 142 patients in CH group,including 137 patients with HCRT-1 reduction and 5 patients without.There were 23 patients in NCH group,including 15 patients with HCRT-1 reduction and 8 patients without.The positive predictive value of typical cataplexy + DQB1* 0602 positive for the reduction of HCRT-1 in CSF was 96.5%.Typical cataplexy + DQB1* 0602 positive had a good consistency with the HCRT-1 reduction in CSF(X^2=26.7,P<0.001).Conclusion Typical cataplexy + DQB1 * 0602 positive has a good predictive value to the HCRT-1 reduction in CSF in patients with narcolepsy.

关 键 词：Predictive PATIENTS NARCOLEPSY 

分 类 号：R[医药卫生]