Central functions of the orexinergic system  

作　　者：Xiao-Yang Zhang Lei Yu Qian-Xing Zhuang Jing-Ning Zhu Jian-Jun Wang 

机构地区：[1]Department of Biological Science and Technology and State Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, Nanjing University

出　　处：《Neuroscience Bulletin》2013年第3期355-365,共11页神经科学通报（英文版）

基　　金：supported by the National Natural Science Foundation of China (30700201, 31070959, 31071021, 31171050);the National Natural Science Foundation of China/Research Grants Council of Hong Kong Joint Research Scheme (30931160433);the Research Fund for the Doctoral Program of Higher Education, Ministry of Education, China (20070284057 and 20100091110016);Program for New Century Excellent Talents in University, Fundamental Research Funds for the Central Universities, Ministry of Education, China (1094020806 and 1095020821);the Natural Science Foundation of Jiangsu Province, China (BK2011014)

摘　　要：The neuropeptide orexin is synthesized by neurons exclusively located in the hypothalamus. However, these neurons send axons over virtually the entire brain and spinal cord and therefore constitute a unique central orexinergic system. It is well known that central orexin plays a crucial role in the regulation of various basic non-somatic and somatic physiological functions, including feeding, energy homeostasis, the sleep/wake cycle, reward, addiction, and neuroendocrine, as well as motor control. Moreover, the absence of orexin results in narcolepsy-cataplexy, a simultaneous somatic and non-somatic dysfunction. In this review, we summarize these central functions of the orexinergic system and associated diseases, and suggest that this system may hold a key position in somatic-non-somatic integration.The neuropeptide orexin is synthesized by neurons exclusively located in the hypothalamus. However, these neurons send axons over virtually the entire brain and spinal cord and therefore constitute a unique central orexinergic system. It is well known that central orexin plays a crucial role in the regulation of various basic non-somatic and somatic physiological functions, including feeding, energy homeostasis, the sleep/wake cycle, reward, addiction, and neuroendocrine, as well as motor control. Moreover, the absence of orexin results in narcolepsy-cataplexy, a simultaneous somatic and non-somatic dysfunction. In this review, we summarize these central functions of the orexinergic system and associated diseases, and suggest that this system may hold a key position in somatic-non-somatic integration.

关 键 词：OREXIN sleep/wake cycle motor control narcolepsy-cataplexy integration of somatic-non-somaticresponses 

分 类 号：R741[医药卫生—神经病学与精神病学]