supported by the National Key Research and Development Program of China grant 2022YFA1302903(T.H.);the National Natural Science Foundation of China grant 91953202(Z.-J.L.);the CAS Strategic Priority Research Program XDB37030104(Z.-J.L.);the National Science Fund for Distinguished Young Scholars 32022038(T.H.);the National Natural Science Foundation of China grants 32230026(Z.-J.L.)and 32271262(T.H.);Shanghai Frontiers Science Center for Bomacromolecules and Precision Medicine.
Dear Editor,G protein-coupled receptors(GPCRs)play a vital role in regulating almost every aspect of human physiology,making up more than one-third of marketed drug targets(Santos et al.,2017).GPCRs orchestrate their ...